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Tbio
CHRFAM7A
CHRNA7-FAM7A fusion protein

Protein Summary
Description
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299847
  • ENSP00000299847
  • ENSG00000166664

Symbol
  • D-10
  • CHRNA7
  • NACHRA7
  • CHRNA7-DR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
cell line
0.72
cell type or tissue
0.72
tissue sample
0.64
phenotype
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.42   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.42   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (4)
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
Alzheimer disease-amyloid secretase pathway
PathwayCommons: panther
Nicotinic acetylcholine receptor signaling pathway
Name
Explore in Pharos
Explore in Source
Alzheimer disease-amyloid secretase pathway
Nicotinic acetylcholine receptor signaling pathway
Protein-Protein Interactions (18)
1 – 10 of 18
OTUD7A
Tbio
Novelty: 0.09531354
Score: 0.807
Data Source: STRINGDB
MTMR10
Tdark
Novelty: 0.24626422
Score: 0.693
Data Source: STRINGDB
HNRNPCL1
Tdark
Novelty: 1.05199828
Score: 0.633
Data Source: STRINGDB
GOLGA8K
Tdark
Novelty: 9.375
Score: 0.604
Data Source: STRINGDB
ARHGAP11B
Tbio
Family: Enzyme
Novelty: 0.0783727
Score: 0.581
Data Source: STRINGDB
SLC35F2
Tbio
Family: Transporter
Novelty: 0.08323418
Score: 0.571
Data Source: STRINGDB
ULK4
Tbio
Family: Kinase
Novelty: 0.05246845
Score: 0.57
Data Source: STRINGDB
FUS
Tbio
Novelty: 0.00065625
Score: 0.544
Data Source: STRINGDB
DOP1B
Tbio
Novelty: 0.14441699
Score: 0.522
Data Source: STRINGDB
USE1
Tbio
Novelty: 0.00904756
Score: 0.519
Data Source: STRINGDB
Publication Statistics
PubMed Score  46.42

PubMed score by year
PubTator Score  138.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer