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Tbio
PLEKHN1
Pleckstrin homology domain-containing family N member 1

Protein Summary
Description
Controls the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR, in cooperation with the RNA stabilizer ELAVL1 (PubMed:29180010). Decreases the stability of the leptin mRNA by antagonizing the function of ELAVL1 by inducing its atypical recruitment from the nucleus to the cytosol (By similarity). Binds to cardiolipin (CL), phosphatidic acid (PA), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidylserine (PS) (PubMed:18191643). Promotes apoptosis by enhancing BAX-BAK hetro-oligomerization via interaction with BID in colon cancer cells (PubMed:29531808) (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379407
  • ENSP00000368717
  • ENSG00000187583
  • ENST00000379409
  • ENSP00000368719
  • ENST00000379410
  • ENSP00000368720

Symbol
  • CLPABP
  • CLPABP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.68
disease
0.58
transcription factor
0.55
tissue
0.52
cell line
0.48


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.94   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 8   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.94   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 8   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (21)
SAMD11
Tdark
Novelty:  0.32977476
Score:  0.679
Data Source:  STRINGDB
PERM1
Tdark
Novelty:  0.15783639
Score:  0.674
Data Source:  STRINGDB
KLHL17
Tdark
Novelty:  0.22103723
Score:  0.624
Data Source:  STRINGDB
TFAP2E
Tbio
Family:  TF
Novelty:  0.07487225
Score:  0.553
Data Source:  STRINGDB
ZCCHC10
Tdark
Novelty:  0.48625249
Score:  0.53
Data Source:  STRINGDB
ZNF396
Tbio
Family:  TF
Novelty:  0.95895478
Score:  0.53
Data Source:  STRINGDB
TMEM212
Tdark
Novelty:  0.94290731
Score:  0.511
Data Source:  STRINGDB
PRTG
Tbio
Novelty:  0.05120525
Score:  0.498
Data Source:  STRINGDB
C3orf67
Tdark
Novelty:  0.89284019
Score:  0.479
Data Source:  STRINGDB
NOC2L
Tbio
Novelty:  0.00226536
Score:  0.469
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.3
59.6
apolipoprotein A 1 measurement
2
2
2
52
high density lipoprotein cholesterol measurement
2
2
2
47.4
alkaline phosphatase measurement
1
1
1
46.9
hip bone size
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
59.6
apolipoprotein A 1 measurement
2
52
high density lipoprotein cholesterol measurement
2
47.4
alkaline phosphatase measurement
1
46.9
hip bone size
1
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pleckstrin homology domain containing N1
VGNC:14064
100608864
Macaque
pleckstrin homology domain containing N1
697918
Mouse
MGI:2387630
231002
Rat
RGD:1311019
298694
Dog
pleckstrin homology domain containing N1
VGNC:44686
489606
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pleckstrin homology domain containing N1
Macaque
pleckstrin homology domain containing N1
Mouse
Rat
Dog
pleckstrin homology domain containing N1
Publication Statistics
PubMed Score 3.94
PubMed score by year
PubTator Score 1.43
PubTator score by year
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Related Publications
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PMID
Year
Title