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Tchem
PARP15
Poly [ADP-ribose] polymerase 15

Protein Summary
Description
Possesses ADP-ribosyltransferase activity (PubMed:16061477, PubMed:25635049). Transcriptional repressor (PubMed:16061477). PARP15 is a macrodomain-containing transcriptional repressor with poly(ADP-ribose) polymerase activity (Aguiar et al., 2005 [PubMed 16061477]).[supplied by OMIM, May 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310366
  • ENSP00000308436
  • ENSG00000173200
  • ENST00000464300
  • ENSP00000417214

Symbol
  • BAL3
  • BAL3
  • ARTD7
  • pART7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.58
cell type or tissue
0.56
histone modification site profile
0.52
tissue sample
0.47
trait
0.46


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.32   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 27   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.32   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 27   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL4089522
Rendered image for CHEMBL4089522
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
calcium measurement
1
10
10
99.7
low density lipoprotein cholesterol measurement
2
2
2
57.1
mean corpuscular hemoglobin concentration
1
1
1
46.1
self reported educational attainment
1
1
1
42.3
mathematical ability
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
calcium measurement
10
99.7
low density lipoprotein cholesterol measurement
2
57.1
mean corpuscular hemoglobin concentration
1
46.1
self reported educational attainment
1
42.3
mathematical ability
1
33.1
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
poly(ADP-ribose) polymerase family member 15
VGNC:2497
460633
Macaque
poly(ADP-ribose) polymerase family member 15
715533
Dog
poly(ADP-ribose) polymerase family member 15
VGNC:53083
608662
Horse
poly(ADP-ribose) polymerase family member 15
100070587
Pig
poly [ADP-ribose] polymerase 15
100520273
Species
Name
OMA
EggNOG
Inparanoid
Chimp
poly(ADP-ribose) polymerase family member 15
Macaque
poly(ADP-ribose) polymerase family member 15
Dog
poly(ADP-ribose) polymerase family member 15
Horse
poly(ADP-ribose) polymerase family member 15
Pig
poly [ADP-ribose] polymerase 15
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q460N3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (24)
1 – 10 of 24
PARP16
Tchem
Family:  Enzyme
Novelty:  0.09651799
Score:  0.724
Data Source:  STRINGDB
NMNAT3
Tbio
Family:  Enzyme
Novelty:  0.03261313
Score:  0.699
Data Source:  STRINGDB
NMNAT2
Tbio
Family:  Enzyme
Novelty:  0.01709189
Score:  0.685
Data Source:  STRINGDB
DTX3L
Tbio
Family:  Enzyme
Novelty:  0.0622833
Score:  0.679
Data Source:  STRINGDB
PARP6
Tchem
Family:  Enzyme
Novelty:  0.10074447
Score:  0.657
Data Source:  STRINGDB
PARP8
Tdark
Family:  Enzyme
Novelty:  0.29808738
Score:  0.651
Data Source:  STRINGDB
PARP3
Tclin
Family:  Enzyme
Novelty:  0.01712237
Score:  0.638
Data Source:  STRINGDB
NADK
Tbio
Family:  Kinase
Novelty:  0.02812925
Score:  0.613
Data Source:  STRINGDB
PARP4
Tchem
Family:  Enzyme
Novelty:  0.02135745
Score:  0.598
Data Source:  STRINGDB
ADPRHL2
Tbio
Family:  Enzyme
Novelty:  0.02261777
Score:  0.586
Data Source:  STRINGDB
Publication Statistics
PubMed Score  12.32

PubMed score by year
PubTator Score  224.86

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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