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Tchem
ZACN
Zinc-activated ligand-gated ion channel

Protein Classes
Protein Summary
Description
Zinc-activated ligand-gated ion channel. LGICZ1 is a zinc-activated ligand-gated ion channel that defines a new subgroup of the cysteine-loop superfamily of ligand-gated ion channels (Davies et al., 2003 [PubMed 12381728]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334586
  • ENSP00000334854
  • ENSG00000186919
  • ENST00000421794
  • ENSP00000391936
  • ENST00000425015
  • ENSP00000397489

Symbol
  • L2
  • LGICZ
  • LGICZ1
  • ZAC
  • L2
  • ZAC
  • ZAC1
  • LGICZ
  • LGICZ1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.73
protein domain
0.73
molecular function
0.7
tissue
0.53
cellular component
0.44


Related Tools
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.19   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.19   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
tubocurarine
chemical structure image
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc activated ion channel
VGNC:9798
468333
Dog
zinc activated ion channel
VGNC:48510
483326
Horse
zinc activated ion channel
VGNC:25122
100630768
Cow
zinc activated ion channel
VGNC:37048
789168
Pig
zinc activated ion channel
100623825
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc activated ion channel
Dog
zinc activated ion channel
Horse
zinc activated ion channel
Cow
zinc activated ion channel
Pig
zinc activated ion channel
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q401N2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (55)
1 – 10 of 55
SLC41A3
Tdark
Family: Transporter
Novelty: 0.20246441
p_int: 0.999931958
p_ni: 0.00003015
p_wrong: 0.000037892
Score: 0.189
Data Source: BioPlex,STRINGDB
EDEM1
Tbio
Family: Enzyme
Novelty: 0.01157706
p_int: 0.999819462
p_ni: 0.000180534
p_wrong: 5e-9
Data Source: BioPlex
TRPM7
Tchem
Family: IC
Novelty: 0.00265096
p_int: 0.999592189
p_ni: 0.000407627
p_wrong: 1.84e-7
Data Source: BioPlex
FAM241A
Tdark
Novelty: 1.04041354
p_int: 0.999509222
p_ni: 0.000489372
p_wrong: 0.000001407
Data Source: BioPlex
SLC43A1
Tbio
Family: Transporter
Novelty: 0.06939259
p_int: 0.999264089
p_ni: 0.000003878
p_wrong: 0.000732033
Score: 0.189
Data Source: BioPlex,STRINGDB
DPY19L4
Tdark
Family: Enzyme
Novelty: 0.99997412
p_int: 0.998326938
p_ni: 0.001673058
p_wrong: 3e-9
Data Source: BioPlex
SLC47A1
Tchem
Family: Transporter
Novelty: 0.00535064
p_int: 0.996017462
p_ni: 0.003980314
p_wrong: 0.000002224
Data Source: BioPlex
FZD7
Tbio
Family: GPCR
Novelty: 0.00916448
p_int: 0.99511971
p_ni: 0.000386472
p_wrong: 0.004493819
Data Source: BioPlex
LRRC8C
Tbio
Novelty: 0.11920205
p_int: 0.9946179
p_ni: 0.005374199
p_wrong: 0.000007901
Data Source: BioPlex
COA1
Tbio
Family: Enzyme
Novelty: 0.49194068
p_int: 0.994337742
p_ni: 0.0009812
p_wrong: 0.004681058
Data Source: BioPlex
Publication Statistics
PubMed Score  3.19

PubMed score by year
PubTator Score  14.95

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer