Tdark ZNF568 Zinc finger protein 568

Protein Summary

Description

Has transcriptional repression activity, partially through the recruitment of the corepressor TRIM28 but has also repression activity independently of this interaction. Essential during embryonic development, where it acts as direct repressor of a placental-specific transcript of IGF2 in early development and regulates convergent extension movements required for axis elongation and tissue morphogenesis in all germ layers. Also important for normal morphogenesis of extraembryonic tissues including the yolk sac, extraembryonic mesoderm and placenta. May enhance proliferation or maintenance of neural stem cells.

Uniprot Accession IDs

• Q3ZCX4
• B4DS92
• E7ER33
• Q6N060
• Q8NA64

Gene Name

• ZNF568

Ensembl ID

• ENST00000333987
• ENSP00000334685
• ENSG00000198453
• ENST00000415168
• ENSP00000394514
• ENST00000455427
• ENSP00000413396
• ENST00000619231
• ENSP00000481819

Symbol

• ZFP568

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.74
protein domain	0.58
microRNA	0.55
cell line	0.52
trait	0.46

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.18   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 114   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.18   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0