Protein Summary
Transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. Binds to PE response elements (PERE) present in the promoter of genes such as ANF/NPPA and acts as a direct transcriptional activator of NPPA. Also acts as a cofactor with GATA4, a key cardiac regulator (By similarity).
- ENST00000523638
- ENSP00000429803
- ENSG00000254004
- ENST00000588993
- ENSP00000467219
- ENST00000592282
- ENSP00000464964
- ENST00000593142
- ENSP00000465834
- ZFP260
- PEX1
- OZRF1
- ZFP260
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
histone modification site profile | 0.92 | ||
transcription factor perturbation | 0.84 | ||
transcription factor binding site profile | 0.75 | ||
gene perturbation | 0.71 | ||
transcription factor | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.56 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 42 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.56 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 42 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0