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Tdark
ZNF260
Zinc finger protein 260

Protein Summary
Description
Transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. Binds to PE response elements (PERE) present in the promoter of genes such as ANF/NPPA and acts as a direct transcriptional activator of NPPA. Also acts as a cofactor with GATA4, a key cardiac regulator (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000523638
  • ENSP00000429803
  • ENSG00000254004
  • ENST00000588993
  • ENSP00000467219
  • ENST00000592282
  • ENSP00000464964
  • ENST00000593142
  • ENSP00000465834

Symbol
  • ZFP260
  • PEX1
  • OZRF1
  • ZFP260
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
transcription factor perturbation
0.84
transcription factor binding site profile
0.75
gene perturbation
0.71
transcription factor
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.56   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 42   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.56   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 42   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0