Tclin TUBB8 Tubulin beta-8 chain

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Tubulin / Tubulin Beta-8 Chain

DTO Classes

Protein / Cellular Structure / Microtubule Family Cytoskeletal Protein / Tubulin / Tubulin Beta-8 Chain

Protein Summary

Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). TUBB8 has a key role in meiotic spindle assembly and oocyte maturation (PubMed:26789871). The protein encoded by this gene represents the primary beta-tubulin subunit of oocytes and the early embryo. Defects in this gene, which is primate-specific, are a cause of oocyte maturation defect 2 and infertility. [provided by RefSeq, Mar 2016]

Uniprot Accession IDs

• Q3ZCM7
• Q5SQX9
• Q8WZ78

Gene Name

• TUBB8

Ensembl ID

• ENST00000568584
• ENSP00000456206
• ENSG00000261456

Symbol

• OOMD
• OOMD2
• bA631M21.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
molecular function	0.93
interacting protein	0.83
cell type or tissue	0.76
cell line	0.63

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.02   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 89   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.02   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 89   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 13

Approved Drugs (13)

Explore Approved Drugs

1 – 10 of 13

docetaxel

TUBB8Tclin

INHIBITOR ID50 : 6.69899988

trastuzumab emtansine

TUBB8Tclin

INHIBITOR :

paclitaxel

TUBB8Tclin

INHIBITOR EC50 : 8.05

brentuximab vedotin

TUBB8Tclin

INHIBITOR :

vinblastine

TUBB8Tclin

INHIBITOR IC50 : 9

vinorelbine

TUBB8Tclin

INHIBITOR :

polatuzumab vedotin

TUBB8Tclin

BINDING AGENT :

enfortumab vedotin

TUBB8Tclin

BINDING AGENT :

eribulin

TUBB8Tclin

INHIBITOR IC50 : 8.22999954

vincristine

TUBB8Tclin

INHIBITOR :

Orthologs (1)

1 – 1 of 1

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	tubulin beta 8 class VIII	VGNC:12516	739035

Species	Name	OMA	EggNOG	Inparanoid
Chimp	tubulin beta 8 class VIII

Protein Structure (0 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q3ZCM7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (999)

Reactome (3)

KEGG (3)

PathwayCommons (2)

WikiPathways (991)

Carboxyterminal post-translational modifications of tubulin (R-HSA-8955332)

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Find Similar Targets

Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Carboxyterminal post-translational modifications of tubulin	38 targets	R-HSA-8955332
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Post-translational protein modification	1450 targets	R-HSA-597592

Name	Explore in Pharos	Explore in Source
Carboxyterminal post-translational modifications of tubulin	38 targets	R-HSA-8955332
Metabolism of proteins	2050 targets	R-HSA-392499
Post-translational protein modification	1450 targets	R-HSA-597592

Gene Ontology Terms (12)

Functions (3)

Components (4)

Processes (5)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
GTP binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
structural constituent of cytoskeleton	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
GTPase activity	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (176)

Explore Interacting Targets

1 – 10 of 176

• See Interactions on String-DB

CAPS

Tbio

Novelty: 0.04549022

p_int: 0.999872904

p_ni: 0.000127096

Data Source: BioPlex

RAB2B

Tdark

Family: Enzyme

Novelty: 0.18567584

p_int: 0.997604518

p_ni: 0.002395482

Score: 0.159

Data Source: BioPlex,STRINGDB

GLMP

Tdark

Novelty: 0.10163099

p_int: 0.997439886

p_ni: 0.002559736

p_wrong: 3.78e-7

Data Source: BioPlex

DNAL4

Tbio

Novelty: 0.15546154

p_int: 0.995280595

p_ni: 0.004719405

Data Source: BioPlex

TPSB2

Tbio

Family: Enzyme

Novelty: 0.00757397

p_int: 0.994681681

p_ni: 0.005318318

p_wrong: 1e-9

Data Source: BioPlex

LRP1

Tbio

Novelty: 0.00200788

p_int: 0.991870456

p_ni: 0.008129544

Data Source: BioPlex

CFB

Tchem

Novelty: 0.00102672

p_int: 0.991046728

p_ni: 0.008953272

Data Source: BioPlex

MGARP

Tbio

Novelty: 0.02883753

p_int: 0.987049292

p_ni: 0.012950708

Data Source: BioPlex

SPANXB1

Tbio

Novelty: 0.19187624

p_int: 0.984762274

p_ni: 0.015237726

Data Source: BioPlex

TUBB

Tclin

Novelty: 0.0038007

p_int: 0.981458425

p_ni: 0.01854157

p_wrong: 5e-9

Score: 0.397

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  16.02

PubMed score by year

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PubTator Score  7.38

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

Complete proteome
Cytoplasm
Cytoskeleton
Disease mutation
GTP-binding
Isopeptide bond
Microtubule
Nucleotide-binding
Phosphoprotein
Polymorphism