Protein Summary
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). TUBB8 has a key role in meiotic spindle assembly and oocyte maturation (PubMed:26789871). The protein encoded by this gene represents the primary beta-tubulin subunit of oocytes and the early embryo. Defects in this gene, which is primate-specific, are a cause of oocyte maturation defect 2 and infertility. [provided by RefSeq, Mar 2016]
- ENST00000568584
- ENSP00000456206
- ENSG00000261456
- OOMD
- OOMD2
- bA631M21.2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.97 | ||
molecular function | 0.93 | ||
interacting protein | 0.83 | ||
cell type or tissue | 0.76 | ||
cell line | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 21.42 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 89 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 21.42 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 89 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 13
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (13)
Active Ligands (0)
Protein-Protein Interactions (176)
RAB2B
Family: Enzyme
Novelty: 0.18567584
p_int: 0.997604518
p_ni: 0.002395482
Score: 0.159
Data Source: BioPlex,STRINGDB
GLMP
Novelty: 0.10163099
p_int: 0.997439886
p_ni: 0.002559736
p_wrong: 3.78e-7
Data Source: BioPlex
TPSB2
Family: Enzyme
Novelty: 0.00757397
p_int: 0.994681681
p_ni: 0.005318318
p_wrong: 1e-9
Data Source: BioPlex
TUBB
Novelty: 0.0038007
p_int: 0.981458425
p_ni: 0.01854157
p_wrong: 5e-9
Score: 0.397
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (999)
Reactome (3)
KEGG (3)
PathwayCommons (2)
WikiPathways (991)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Carboxyterminal post-translational modifications of tubulin | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Post-translational protein modification | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Carboxyterminal post-translational modifications of tubulin | ||||
Metabolism of proteins | ||||
Post-translational protein modification | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (3)
Components (4)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (1)
1 – 1 of 1
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | tubulin beta 8 class VIII | VGNC:12516 | 739035 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | tubulin beta 8 class VIII | |||||
Publication Statistics
PubMed Score 21.42
PubMed score by year
PubTator Score 7.38
PubTator score by year
Related Publications
Text Mined References (14)
GeneRif Annotations (8)
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PMID | Year | Title |
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