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Tbio
RABL6
Rab-like protein 6

Protein Summary
Description
May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A. This gene encodes a member of the Ras superfamily of small GTPases. The encoded protein binds to both GTP and GDP and may play a role in cell growth and survival. Overexpression of this gene may play a role in breast cancer tumorigenesis, and pseudogenes of this gene are located on the long arm of chromosome 2 and the short arm of chromosome 18. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311502
  • ENSP00000311134
  • ENSG00000196642
  • ENST00000357466
  • ENSP00000350056
  • ENST00000371663
  • ENSP00000360727
  • ENST00000371671
  • ENSP00000360736

Symbol
  • C9orf86
  • PARF
  • PARF
  • RBEL1
  • pp8875
  • C9orf86
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
interacting protein
0.84
kinase perturbation
0.81
molecular function
0.76
tissue sample
0.7


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.82   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.82   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
RAB, member RAS oncogene family like 6
709111
Mouse
MGI:2442633
227624
Rat
RGD:1307615
362084
Dog
RAB, member RAS oncogene family like 6
VGNC:45307
480675
Horse
RAB, member RAS oncogene family like 6
VGNC:22139
100068092
Species
Name
OMA
EggNOG
Inparanoid
Macaque
RAB, member RAS oncogene family like 6
Mouse
Rat
Dog
RAB, member RAS oncogene family like 6
Horse
RAB, member RAS oncogene family like 6
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (66)
1 – 10 of 66
AP3S1
Tbio
Novelty: 0.12425009
p_int: 0.999999918
p_ni: 7.5e-8
p_wrong: 7e-9
Score: 0.235
Data Source: BioPlex,STRINGDB
AP3M1
Tbio
Novelty: 0.5036622
p_int: 0.999999259
p_ni: 7.4e-7
Score: 0.328
Data Source: BioPlex,STRINGDB
PDILT
Tdark
Family: Enzyme
Novelty: 0.22502488
p_int: 0.999539501
p_ni: 0.000460485
p_wrong: 1.4e-8
Data Source: BioPlex
SREK1IP1
Tdark
Novelty: 1.39429464
p_int: 0.994558908
p_ni: 0.005365033
p_wrong: 0.000076059
Score: 0.197
Data Source: BioPlex,STRINGDB
MTUS2
Tbio
Novelty: 0.13504593
p_int: 0.981551557
p_ni: 0.018440206
p_wrong: 0.000008237
Data Source: BioPlex
PLK2
Tchem
Family: Kinase
Novelty: 0.00750465
p_int: 0.96373865
p_ni: 0.036261347
p_wrong: 3e-9
Score: 0.223
Data Source: BioPlex,STRINGDB
JMJD6
Tbio
Family: Enzyme
Novelty: 0.00305479
p_int: 0.948215666
p_ni: 0.051775352
p_wrong: 0.000008982
Data Source: BioPlex
ID2
Tbio
Family: TF
Novelty: 0.00256364
p_int: 0.923721191
p_ni: 0.039671295
p_wrong: 0.036607513
Data Source: BioPlex
ZNF684
Tdark
Family: TF
Novelty: 7.06924999
p_int: 0.90463785
p_ni: 0.084091146
p_wrong: 0.011271004
Score: 0.187
Data Source: BioPlex,STRINGDB
AMTN
Tbio
Novelty: 0.02514528
p_int: 0.863122708
p_ni: 0.10557725
p_wrong: 0.031300042
Score: 0.19
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  8.82

PubMed score by year
PubTator Score  10.18

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer