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Tbio
CCDC88A
Girdin

Protein Summary
Description
Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself (By similarity). Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Essential for the integrity of the actin cytoskeleton and for cell migration (PubMed:16139227). Required for formation of actin stress fibers and lamellipodia (PubMed:15882442). May be involved in membrane sorting in the early endosome (PubMed:15882442). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263630
  • ENSP00000263630
  • ENSG00000115355
  • ENST00000336838
  • ENSP00000338728
  • ENST00000436346
  • ENSP00000410608
  • ENST00000642200
  • ENSP00000495919
  • ENST00000643413
  • ENSP00000494811
  • ENST00000646796
  • ENSP00000493703

Symbol
  • APE
  • GRDN
  • KIAA1212
  • APE
  • GIV
  • GRDN
  • PEHO
  • HkRP1
  • PEHOL
  • GIRDIN
  • KIAA1212
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
transcription factor binding site profile
0.91
gene perturbation
0.78
trait
0.75
biological process
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.44   (req: < 5)
Gene RIFs: 90   (req: <= 3)
Antibodies: 225   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.44   (req: >= 5)
Gene RIFs: 90   (req: > 3)
Antibodies: 225   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0