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Tbio
CCDC88A
Girdin

Protein Summary
Description
Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself (By similarity). Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Essential for the integrity of the actin cytoskeleton and for cell migration (PubMed:16139227). Required for formation of actin stress fibers and lamellipodia (PubMed:15882442). May be involved in membrane sorting in the early endosome (PubMed:15882442). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263630
  • ENSP00000263630
  • ENSG00000115355
  • ENST00000336838
  • ENSP00000338728
  • ENST00000436346
  • ENSP00000410608
  • ENST00000642200
  • ENSP00000495919
  • ENST00000643413
  • ENSP00000494811
  • ENST00000646796
  • ENSP00000493703

Symbol
  • APE
  • GRDN
  • KIAA1212
  • APE
  • GIV
  • GRDN
  • PEHO
  • HkRP1
  • PEHOL
  • GIRDIN
  • KIAA1212
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
transcription factor binding site profile
0.91
gene perturbation
0.78
trait
0.75
biological process
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114   (req: < 5)
Gene RIFs: 70   (req: <= 3)
Antibodies: 225   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114   (req: >= 5)
Gene RIFs: 70   (req: > 3)
Antibodies: 225   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (65)
PIP
Tbio
Novelty:  0.00208509
p_int:  0.999997079
p_ni:  0.000002921
Data Source:  BioPlex
JADE2
Tbio
Family:  Epigenetic
Novelty:  0.19820849
p_int:  0.999799783
p_ni:  0.000200217
Data Source:  BioPlex
CCDC136
Tbio
Novelty:  0.09279967
p_int:  0.999489662
p_ni:  0.000510338
Score:  0.183
Data Source:  BioPlex,STRINGDB
NUP62
Tbio
Novelty:  0.01432724
p_int:  0.999296798
p_ni:  0.000703202
Data Source:  BioPlex
RAPGEF5
Tbio
Novelty:  0.02449802
p_int:  0.990948434
p_ni:  0.009051566
Score:  0.156
Data Source:  BioPlex,STRINGDB
RFTN2
Tdark
Novelty:  0.99330616
p_int:  0.990607329
p_ni:  0.009392657
p_wrong:  1.4e-8
Score:  0.169
Data Source:  BioPlex,STRINGDB
ABTB2
Tdark
Novelty:  0.45729157
p_int:  0.990595696
p_ni:  0.009404304
Data Source:  BioPlex
CYTH4
Tbio
Novelty:  0.05783135
p_int:  0.984721745
p_ni:  0.015278255
Data Source:  BioPlex
SKP2
Tbio
Family:  Enzyme
Novelty:  0.00182658
p_int:  0.983124588
p_ni:  0.016875403
p_wrong:  8e-9
Data Source:  BioPlex
MLF1
Tbio
Novelty:  0.0239522
p_int:  0.98283502
p_ni:  0.01716498
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (22)
Find Similar Targets
Items per page:
1 – 5 of 22
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Mesodermal Commitment Pathway
WikiPathways
Mesodermal Commitment Pathway
WikiPathways
Mesodermal Commitment Pathway
WikiPathways
Mesodermal Commitment Pathway
WikiPathways
PDGF Pathway
Name
Explore in Pharos
Explore in Source
Mesodermal Commitment Pathway
Mesodermal Commitment Pathway
Mesodermal Commitment Pathway
Mesodermal Commitment Pathway
PDGF Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (32)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
21.5
self reported educational attainment
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
21.5
self reported educational attainment
1
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 88A
VGNC:205
459241
Macaque
coiled-coil domain containing 88A
717103
Mouse
MGI:1925177
108686
Rat
RGD:1306694
305605
Dog
coiled-coil domain containing 88A
VGNC:38867
481375
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 88A
Macaque
coiled-coil domain containing 88A
Mouse
Rat
Dog
coiled-coil domain containing 88A
Publication Statistics
PubMed Score 114.00
PubMed score by year
PubTator Score 77.73
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title