Tbio CCDC88A Girdin

Protein Summary

Description

Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself (By similarity). Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Essential for the integrity of the actin cytoskeleton and for cell migration (PubMed:16139227). Required for formation of actin stress fibers and lamellipodia (PubMed:15882442). May be involved in membrane sorting in the early endosome (PubMed:15882442). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (PubMed:27623382). This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Uniprot Accession IDs

• Q3V6T2
• A1IGE7
• B7ZM78
• C9JG83
• Q53SF1
• Q581G3
• Q5HYD0
• Q7Z339
• Q7Z3C5

Gene Name

• CCDC88A

Ensembl ID

• ENST00000263630
• ENSP00000263630
• ENSG00000115355
• ENST00000336838
• ENSP00000338728
• ENST00000436346
• ENSP00000410608
• ENST00000642200
• ENSP00000495919
• ENST00000643413
• ENSP00000494811
• ENST00000646796
• ENSP00000493703

Symbol

• APE
• GRDN
• KIAA1212
• APE
• GIV
• GRDN
• PEHO
• HkRP1
• PEHOL
• GIRDIN
• KIAA1212

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.96
transcription factor binding site profile	0.91
gene perturbation	0.78
trait	0.75
biological process	0.73

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Girdin

Protein / Enzyme Modulator / Kinase Modulator / Girdin

DTO Classes

Protein / Enzyme Modulator / Kinase Modulator / Girdin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.44   (req: < 5)

Gene RIFs: 91   (req: <= 3)

Antibodies: 225   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.44   (req: >= 5)

Gene RIFs: 91   (req: > 3)

Antibodies: 225   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0