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Tchem
MOGAT2
2-acylglycerol O-acyltransferase 2

Protein Summary
Description
Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity. The protein encoded by this gene is an enzyme that catalyzes the synthesis of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. The encoded protein is important in the uptake of dietary fat by the small intestine. This protein forms a complex with diacylglycerol O-acyltransferase 2 in the endoplasmic reticulum, and this complex catalyzes the synthesis of triacylglycerol. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000198801
  • ENSP00000198801
  • ENSG00000166391
  • ENST00000525093
  • ENSP00000436537
  • ENST00000526712
  • ENSP00000436283

Symbol
  • DC5
  • DGAT2L5
  • hDC5
  • MGAT2
  • DGAT2L5
  • DGAT2L5.
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
1
gene perturbation
0.81
cell line
0.6
PubMedID
0.54
virus perturbation
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.68   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.68   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 173
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (173)
1 – 10 of 173
CHEMBL3655069
chemical structure image
CHEMBL3655064
chemical structure image
CHEMBL2441600
chemical structure image
CHEMBL2376303
chemical structure image
CHEMBL3654953,CHEMBL3654960
chemical structure image
CHEMBL3655068
chemical structure image
CHEMBL3654998,CHEMBL3655033
chemical structure image
CHEMBL3655071
chemical structure image
CHEMBL3655040,CHEMBL3655038
chemical structure image
CHEMBL3655020
chemical structure image
Pathways (8)
Metabolism (R-HSA-1430728)

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Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Triglyceride biosynthesis
Reactome
Triglyceride metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Triglyceride biosynthesis
Triglyceride metabolism
Protein-Protein Interactions (77)
1 – 10 of 77
NME2P1
Tdark
Family: Kinase
p_int: 0.99393344
p_ni: 0.006066316
p_wrong: 2.44e-7
Data Source: BioPlex
DDI2
Tdark
Novelty: 0.14978602
p_int: 0.94888187
p_ni: 0.05111813
Data Source: BioPlex
DGAT1
Tclin
Family: Enzyme
Novelty: 0.0015819
Score: 0.99
Data Source: STRINGDB
MGLL
Tchem
Family: Enzyme
Novelty: 0.00291863
Score: 0.95
Data Source: STRINGDB
PLPP4
Tbio
Family: Enzyme
Novelty: 0.36878578
Score: 0.915
Data Source: STRINGDB
PLPP5
Tbio
Family: Enzyme
Novelty: 0.17356459
Score: 0.915
Data Source: STRINGDB
AGK
Tbio
Family: Enzyme
Novelty: 0.01192407
Score: 0.911
Data Source: STRINGDB
MOGAT3
Tbio
Family: Enzyme
Novelty: 0.15187127
Score: 0.908
Data Source: STRINGDB
DGAT2
Tchem
Family: Enzyme
Novelty: 0.00706568
Score: 0.906
Data Source: STRINGDB
LPL
Tchem
Family: Enzyme
Novelty: 0.00074704
Score: 0.904
Data Source: STRINGDB
Publication Statistics
PubMed Score  16.68

PubMed score by year
PubTator Score  15.89

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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