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Tbio
ALDH1L2
Mitochondrial 10-formyltetrahydrofolate dehydrogenase

Protein Summary
Description
This gene encodes a member of both the aldehyde dehydrogenase superfamily and the formyl transferase superfamily. This member is the mitochondrial form of 10-formyltetrahydrofolate dehydrogenase (FDH), which converts 10-formyltetrahydrofolate to tetrahydrofolate and CO2 in an NADP(+)-dependent reaction, and plays an essential role in the distribution of one-carbon groups between the cytosolic and mitochondrial compartments of the cell. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258494
  • ENSP00000258494
  • ENSG00000136010
  • ENST00000552270
  • ENSP00000447538

Symbol
  • mtFDH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
virus perturbation
0.94
interacting protein
0.77
microRNA
0.74
gene perturbation
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.26   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.26   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (24)
1 – 10 of 24
SUGT1
Tbio
Novelty:  0.1042721
p_int:  0.967196497
p_ni:  0.032803503
Score:  0.203
Data Source:  BioPlex,STRINGDB
ALDH1L1
Tbio
Family:  Enzyme
Novelty:  0.01123871
p_int:  0.931617438
p_ni:  0.068382562
Score:  0.895
Data Source:  BioPlex,STRINGDB
WDR11
Tbio
Novelty:  0.00560058
p_int:  0.896387337
p_ni:  0.103612663
Score:  0.738
Data Source:  BioPlex,STRINGDB
ADAM18
Tdark
Family:  Enzyme
Novelty:  0.22622379
p_int:  0.858923964
p_ni:  0.141076036
Data Source:  BioPlex
SHMT2
Tchem
Family:  Enzyme
Novelty:  0.00234505
Score:  0.969
Data Source:  STRINGDB
MTHFD2
Tchem
Family:  Enzyme
Novelty:  0.01776594
Score:  0.965
Data Source:  STRINGDB
SHMT1
Tbio
Family:  Enzyme
Novelty:  0.00200739
Score:  0.964
Data Source:  STRINGDB
MTHFD1
Tchem
Family:  Enzyme
Novelty:  0.0071938
Score:  0.961
Data Source:  STRINGDB
MTHFD2L
Tdark
Family:  Enzyme
Novelty:  0.18530504
Score:  0.944
Data Source:  STRINGDB
FTCD
Tbio
Family:  Enzyme
Novelty:  0.02266041
Score:  0.936
Data Source:  STRINGDB
Pathways (6)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of folate and pterines
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of folate and pterines
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
1
2
52.4
total cholesterol measurement
1
1
1
52
mathematical ability
1
1
1
27.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
52.4
total cholesterol measurement
1
52
mathematical ability
1
27.3
Find similar targets by:
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aldehyde dehydrogenase 1 family member L2
VGNC:4917
452195
Macaque
aldehyde dehydrogenase 1 family member L2
701242
Mouse
MGI:2444680
216188
Rat
RGD:1309458
299699
Dog
aldehyde dehydrogenase 1 family member L2
VGNC:37785
474534
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aldehyde dehydrogenase 1 family member L2
Macaque
aldehyde dehydrogenase 1 family member L2
Mouse
Rat
Dog
aldehyde dehydrogenase 1 family member L2
Publication Statistics
PubMed Score 17.26
PubMed score by year
PubTator Score 4.35
PubTator score by year