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Tbio
SP6
Transcription factor Sp6

Protein Summary
Description
Promotes cell proliferation. SP6 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes (Scohy et al., 2000 [PubMed 11087666]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342234
  • ENSP00000340799
  • ENSG00000189120
  • ENST00000536300
  • ENSP00000438209

Symbol
  • KLF14
  • EPFN
  • KLF14
  • EPIPROFIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.55
cell type or tissue
0.54
microRNA
0.5
tissue sample
0.5
cell line
0.48


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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 486.49   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 155   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 486.49   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Sp6 transcription factor
VGNC:12682
455179
Macaque
Sp6 transcription factor
694717
Mouse
MGI:1932575
83395
Rat
RGD:1306768
363672
Dog
Sp6 transcription factor
VGNC:46689
491047
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Sp6 transcription factor
Macaque
Sp6 transcription factor
Mouse
Rat
Dog
Sp6 transcription factor
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q3SY56-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (55)
1 – 10 of 55
RMC1
Tbio
Novelty: 0.02804116
p_int: 0.99999998
p_ni: 2e-8
p_wrong: 1e-9
Score: 0.29
Data Source: BioPlex,STRINGDB
MON1A
Tbio
Novelty: 0.04537045
p_int: 0.999999869
p_ni: 1.31e-7
p_wrong: 1e-9
Score: 0.521
Data Source: BioPlex,STRINGDB
DNAAF3
Tbio
Novelty: 0.06768631
p_int: 0.999995856
p_ni: 2.68e-7
p_wrong: 0.000003875
Score: 0.532
Data Source: BioPlex,STRINGDB
SORL1
Tbio
Novelty: 0.00380895
p_int: 0.999768284
p_ni: 0.000231716
Data Source: BioPlex
GNB2
Tbio
Novelty: 0.08682553
p_int: 0.945930859
p_ni: 0.054066452
p_wrong: 0.000002689
Data Source: BioPlex
CCZ1B
Tdark
Novelty: 0.09724624
p_int: 0.923307052
p_ni: 0.076692948
Score: 0.243
Data Source: BioPlex,STRINGDB
TRAF7
Tbio
Family: Enzyme
Novelty: 0.02437761
p_int: 0.788771419
p_ni: 0.211227901
p_wrong: 6.79e-7
Score: 0.212
Data Source: BioPlex,STRINGDB
LIPN
Tbio
Family: Enzyme
Novelty: 0.00135912
Score: 0.86
Data Source: STRINGDB
MMP28
Tbio
Family: Enzyme
Novelty: 0.01679444
Score: 0.805
Data Source: STRINGDB
ACRV1
Tbio
Novelty: 0.00291978
Score: 0.737
Data Source: STRINGDB
Publication Statistics
PubMed Score  486.49

PubMed score by year
PubTator Score  429.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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