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Tbio
ARL13B
ADP-ribosylation factor-like protein 13B

Protein Summary
Description
Cilium-specific protein required to control the microtubule-based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic interneurons in the developing cerebral cortex. May regulate endocytic recycling traffic; however, additional evidences are required to confirm these data. This gene encodes a member of the ADP-ribosylation factor-like family. The encoded protein is a small GTPase that contains both N-terminal and C-terminal guanine nucleotide-binding motifs. This protein is localized in the cilia and plays a role in cilia formation and in maintenance of cilia. Mutation ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303097
  • ENSP00000306225
  • ENSG00000169379
  • ENST00000394222
  • ENSP00000377769
  • ENST00000471138
  • ENSP00000420780
  • ENST00000535334
  • ENSP00000445145

Symbol
  • ARL2L1
  • JBTS8
  • ARL2L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.76
cellular component
0.67
cell type or tissue
0.64
microRNA
0.58
protein domain
0.58


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.7   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.7   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADP ribosylation factor like GTPase 13B
VGNC:6164
460534
Macaque
ADP ribosylation factor like GTPase 13B
694959
Mouse
MGI:1915396
68146
Rat
RGD:1584979
304037
Dog
ADP ribosylation factor like GTPase 13B
VGNC:38106
487934
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADP ribosylation factor like GTPase 13B
Macaque
ADP ribosylation factor like GTPase 13B
Mouse
Rat
Dog
ADP ribosylation factor like GTPase 13B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q3SXY8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
ARL13B-mediated ciliary trafficking of INPP5E (R-HSA-5624958)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ARL13B-mediated ciliary trafficking of INPP5E
Reactome
Cargo trafficking to the periciliary membrane
Reactome
Cilium Assembly
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
ARL13B-mediated ciliary trafficking of INPP5E
Cargo trafficking to the periciliary membrane
Cilium Assembly
Organelle biogenesis and maintenance
Gene Ontology Terms (17)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (181)
1 – 10 of 181
TTC30A
Tdark
Novelty: 1.41742212
p_int: 0.999998911
p_ni: 0.000001066
p_wrong: 2.2e-8
Score: 0.87
Data Source: BioPlex,STRINGDB
IFT81
Tbio
Novelty: 0.01610195
p_int: 0.999950362
p_ni: 0.000049638
Score: 0.869
Data Source: BioPlex,STRINGDB
IFT46
Tdark
Novelty: 0.11310911
p_int: 0.999922478
p_ni: 0.000077511
p_wrong: 1e-8
Score: 0.923
Data Source: BioPlex,STRINGDB
IFT74
Tbio
Novelty: 0.07195266
p_int: 0.99986162
p_ni: 0.00013838
Score: 0.915
Data Source: BioPlex,STRINGDB
IFT52
Tbio
Novelty: 0.04183122
p_int: 0.999594236
p_ni: 0.000405161
p_wrong: 6.03e-7
Score: 0.908
Data Source: BioPlex,STRINGDB
IFT22
Tbio
Family: Enzyme
Novelty: 0.18342877
p_int: 0.998918342
p_ni: 0.001081642
p_wrong: 1.6e-8
Score: 0.951
Data Source: BioPlex,STRINGDB
ANKRD50
Tdark
Novelty: 0.7929169
p_int: 0.995742485
p_ni: 0.000003469
p_wrong: 0.004254046
Score: 0.374
Data Source: BioPlex,STRINGDB
MINDY2
Tbio
Novelty: 0.46783751
p_int: 0.97620354
p_ni: 0.02379646
Score: 0.185
Data Source: BioPlex,STRINGDB
STK25
Tchem
Family: Kinase
Novelty: 0.03229688
p_int: 0.961135248
p_ni: 0.03886475
p_wrong: 2e-9
Score: 0.211
Data Source: BioPlex,STRINGDB
MAPK14
Tchem
Family: Kinase
Novelty: 0.00045138
p_int: 0.946053321
p_ni: 0.053946679
Score: 0.247
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  71.70

PubMed score by year
PubTator Score  22.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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