You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PLA2G4E
Cytosolic phospholipase A2 epsilon

Protein Summary
Description
Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. This gene encodes a member of the cytosolic phospholipase A2 group IV family. Members of this family are involved in regulation of membrane tubule-mediated transport. The enzyme encoded by this member of the family plays a role in trafficking through the clathrin-independent endocytic pathway. The enzyme regulates the recycling process via formation of tubules that transport internalized clathrin-independent cargo proteins back to the cell surface. [provided by RefSeq, Jan 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000399518
  • ENSP00000382434
  • ENSG00000188089
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
0.78
PubMedID
0.58
hub protein
0.49
cellular component
0.48
phenotype
0.47


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.43   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 66   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.43   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (93)
TBC1D22B
Tbio
Novelty:  0.49852962
p_int:  0.999941319
p_ni:  0.000020166
p_wrong:  0.000038515
Data Source:  BioPlex
ZIC1
Tbio
Family:  TF
Novelty:  0.00491601
p_int:  0.99906458
p_ni:  0.000195099
p_wrong:  0.000740322
Score:  0.211
Data Source:  BioPlex,STRINGDB
CDK15
Tchem
Family:  Kinase
Novelty:  0.3870338
p_int:  0.996087835
p_ni:  0.000014159
p_wrong:  0.003898006
Score:  0.214
Data Source:  BioPlex,STRINGDB
PLA2G7
Tchem
Family:  Enzyme
Novelty:  0.00270949
Score:  0.863
Data Source:  STRINGDB
PLD1
Tchem
Family:  Enzyme
Novelty:  0.00608142
Score:  0.848
Data Source:  STRINGDB
PLD2
Tchem
Family:  Enzyme
Novelty:  0.00331129
Score:  0.833
Data Source:  STRINGDB
Q5JWF2
Tbio
Novelty:  0.00284739
Score:  0.83
Data Source:  STRINGDB
P63092
Tbio
Novelty:  0.00284739
Score:  0.83
Data Source:  STRINGDB
P84996
Tbio
Novelty:  0.00284739
Score:  0.83
Data Source:  STRINGDB
O95467
Tbio
Novelty:  0.00284739
Score:  0.83
Data Source:  STRINGDB
Nearest Tclin Targets (5)
Explore Nearest Tclin Targets
Pathways (78)
Acyl chain remodelling of PC (R-HSA-1482788)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acyl chain remodelling of PC
Reactome
Acyl chain remodelling of PE
Reactome
Acyl chain remodelling of PI
Reactome
Acyl chain remodelling of PS
Reactome
Glycerophospholipid biosynthesis
Name
Explore in Pharos
Explore in Source
Acyl chain remodelling of PC
Acyl chain remodelling of PE
Acyl chain remodelling of PI
Acyl chain remodelling of PS
Glycerophospholipid biosynthesis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations ()
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
4
4
4
97.9
neutrophil count
3
5
5
97.1
myeloid white cell count
2
3
3
95.6
leukocyte count
2
4
4
93.1
granulocyte count
1
2
2
81.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
4
97.9
neutrophil count
5
97.1
myeloid white cell count
3
95.6
leukocyte count
4
93.1
granulocyte count
2
81.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phospholipase A2 group IVE
VGNC:8284
467664
Mouse
MGI:1919144
329502
Rat
RGD:1310595
296091
Dog
phospholipase A2 group IVE
VGNC:44628
487514
Horse
phospholipase A2 group IVE
VGNC:21515
100071038
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phospholipase A2 group IVE
Mouse
Rat
Dog
phospholipase A2 group IVE
Horse
phospholipase A2 group IVE
Publication Statistics
PubMed Score 6.43
PubMed score by year
PubTator Score 1.94
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title