Tbio TMEM30B Cell cycle control protein 50B

Protein Summary

Description

Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate (Probable). Can mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2 and ATP8B4 from the ER to the plasma membrane.

Uniprot Accession IDs

• Q3MIR4
• B3KR84
• Q14D00

Gene Name

• TMEM30B

Ensembl ID

• ENST00000555868
• ENSP00000450842
• ENSG00000182107

Symbol

• CDC50B
• CDC50B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.84
transcription factor perturbation	0.8
virus perturbation	0.55
transcription factor binding site profile	0.54
microRNA	0.51

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.92   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 113   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.92   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0