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Tbio
TBC1D25
TBC1 domain family member 25

Protein Summary
Description
Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes. This gene encodes a protein with a TBC domain and functions as a Rab GTPase activating protein. The encoded protein is involved in the fusion of autophagosomes with endosomes and lysosomes. This gene was previously known as ornithine aminotransferase-like 1, but has no similarity to ornithine aminotransferase. [provided by RefSeq, Jan 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376771
  • ENSP00000365962
  • ENSG00000068354
  • ENST00000481090
  • ENSP00000476787

Symbol
  • OATL1
  • MG81
  • OATL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.81
kinase perturbation
0.54
transcription factor binding site profile
0.54
tissue
0.52
tissue sample
0.51


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.88   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 36   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.88   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 36   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
TBC1 domain family member 25
710596
Mouse
MGI:2444862
209815
Rat
RGD:1559711
302552
Dog
TBC1 domain family member 25
VGNC:47144
491866
Horse
TBC1 domain family member 25
VGNC:23906
100061931
Species
Name
OMA
EggNOG
Inparanoid
Macaque
TBC1 domain family member 25
Mouse
Rat
Dog
TBC1 domain family member 25
Horse
TBC1 domain family member 25
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q3MII6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
Rab regulation of trafficking
Reactome
TBC/RABGAPs
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
Rab regulation of trafficking
TBC/RABGAPs
Vesicle-mediated transport
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (64)
1 – 10 of 64
ATF4
Tbio
Family:  TF
Novelty:  0.00253408
p_int:  0.999994505
p_ni:  0.000005495
Score:  0.689
Data Source:  BioPlex,STRINGDB
GABARAPL1
Tbio
Novelty:  0.00212657
p_int:  0.999696572
p_ni:  2.64e-7
p_wrong:  0.000303164
Score:  0.792
Data Source:  BioPlex,STRINGDB
GABARAP
Tbio
Novelty:  0.00444901
p_int:  0.999669652
p_ni:  0.000035326
p_wrong:  0.000295023
Score:  0.958
Data Source:  BioPlex,Reactome,STRINGDB
GABARAPL2
Tbio
Novelty:  0.0022546
p_int:  0.974431357
p_ni:  0.025568643
Score:  0.978
Data Source:  BioPlex,Reactome,STRINGDB
OMA1
Tbio
Family:  Enzyme
Novelty:  0.00963387
p_int:  0.801390217
p_ni:  0.19845517
p_wrong:  0.000154613
Score:  0.208
Data Source:  BioPlex,STRINGDB
RAB33B
Tbio
Family:  Enzyme
Novelty:  0.06381712
Score:  0.962
Data Source:  STRINGDB
MAP1LC3B
Tbio
Novelty:  0.00101276
Score:  0.955
Data Source:  Reactome,STRINGDB
RAB33A
Tbio
Family:  Enzyme
Novelty:  0.11617001
Score:  0.921
Data Source:  STRINGDB
ELK1
Tbio
Family:  TF
Novelty:  0.21670414
Score:  0.762
Data Source:  STRINGDB
TFE3
Tbio
Family:  TF
Novelty:  0.00266214
Score:  0.727
Data Source:  STRINGDB
Publication Statistics
PubMed Score  16.88

PubMed score by year
PubTator Score  13.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer