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Tbio
TKFC
Triokinase/FMN cyclase

Protein Summary
Description
Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1-mediated cellular antiviral response (PubMed:17600090). This gene is a member of the family of dihydroxyacetone kinases, which have a protein structure distinct from other kinases. The product of this gene phosphorylates dihydroxyacetone, and also catalyzes the formation of riboflavin 4',5'-phosphate (aka cyclin FMN) from FAD. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394900
  • ENSP00000378360
  • ENSG00000149476

Symbol
  • DAK
  • DAK
  • NET45
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.97
transcription factor binding site profile
0.78
histone modification site profile
0.73
tissue sample
0.72
cell type or tissue
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 246.64   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 246.64   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
38.8
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
triokinase and FMN cyclase
VGNC:6692
466626
Macaque
triokinase and FMN cyclase
694117
Mouse
MGI:2385084
225913
Rat
RGD:1311026
361730
Dog
triokinase and FMN cyclase
VGNC:47390
483800
Species
Name
OMA
EggNOG
Inparanoid
Chimp
triokinase and FMN cyclase
Macaque
triokinase and FMN cyclase
Mouse
Rat
Dog
triokinase and FMN cyclase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q3LXA3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (13)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (R-HSA-168928)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Fructose catabolism
Reactome
Fructose metabolism
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Fructose catabolism
Fructose metabolism
Immune System
Innate Immune System
Gene Ontology Terms (15)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (63)
1 – 10 of 63
ARL8A
Tbio
Family:  Enzyme
Novelty:  0.12499089
p_int:  0.999963172
p_ni:  0.000036495
p_wrong:  3.33e-7
Data Source:  BioPlex
DEFA1
Tbio
Novelty:  0.01027492
p_int:  0.999952083
p_ni:  0.000047885
p_wrong:  3.2e-8
Data Source:  BioPlex
IFT20
Tbio
Novelty:  0.03005088
p_int:  0.999949052
p_ni:  0.000050945
p_wrong:  3e-9
Data Source:  BioPlex
RDH12
Tbio
Family:  Enzyme
Novelty:  0.016003
p_int:  0.999859658
p_ni:  0.000086344
p_wrong:  0.000053998
Score:  0.316
Data Source:  BioPlex,STRINGDB
RP2
Tbio
Novelty:  0.12345247
p_int:  0.99163695
p_ni:  0.001036844
p_wrong:  0.007326207
Score:  0.165
Data Source:  BioPlex,STRINGDB
SNRNP27
Tbio
Novelty:  0.0175187
p_int:  0.904131631
p_ni:  0.000131928
p_wrong:  0.095736441
Data Source:  BioPlex
IQCF1
Tdark
Novelty:  0.78525464
p_int:  0.895626423
p_ni:  0.000197346
p_wrong:  0.10417623
Score:  0.175
Data Source:  BioPlex,STRINGDB
CYB5B
Tbio
Novelty:  0.09395308
p_int:  0.874684084
p_ni:  0.005916131
p_wrong:  0.119399784
Data Source:  BioPlex
TPI1
Tbio
Family:  Enzyme
Novelty:  0.00074652
Score:  0.96
Data Source:  STRINGDB
IFIH1
Tbio
Family:  Enzyme
Novelty:  0.00111499
Score:  0.956
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  246.64

PubMed score by year
PubTator Score  56.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer