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Tdark
KRTAP6-1
Keratin-associated protein 6-1

Protein Summary
Description
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329122
  • ENSP00000332690
  • ENSG00000184724

Symbol
  • C21orf103
  • KAP6.1
  • KAP6.1
  • C21orf103
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.49
tissue
0.36
cell line
0.35
PubMedID
0.3
cellular component
0.28


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.4   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.4   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q3LI64-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Gene Ontology Terms (3)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (87)
1 – 10 of 87
KRTAP8-1
Tbio
Novelty: 0.18211237
Score: 0.692
Data Source: STRINGDB
KRTAP11-1
Tbio
Novelty: 0.20865014
Score: 0.633
Data Source: STRINGDB
KRTAP22-1
Tdark
Novelty: 0.75498951
Score: 0.6
Data Source: STRINGDB
KRTAP6-2
Tdark
Novelty: 1.37501842
Score: 0.597
Data Source: STRINGDB
KRTAP12-2
Tdark
Novelty: 94.37239583
Score: 0.582
Data Source: STRINGDB
KRTAP7-1
Tdark
Novelty: 0.31372157
Score: 0.572
Data Source: STRINGDB
KRTAP4-3
Tbio
Novelty: 1.28310177
Score: 0.565
Data Source: STRINGDB
KRTAP16-1
Tdark
Novelty: 94.37239583
Score: 0.558
Data Source: STRINGDB
KRTAP2-2
Tdark
Novelty: 3.83376619
Score: 0.558
Data Source: STRINGDB
KRTAP24-1
Tdark
Novelty: 0.3470695
Score: 0.556
Data Source: STRINGDB
Publication Statistics
PubMed Score  3.40

PubMed score by year
PubTator Score  0.11

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer