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Tdark
USP41
Putative ubiquitin carboxyl-terminal hydrolase 41

Protein Summary
Description
May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000454608
  • ENSP00000414922
  • ENSG00000161133
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
cell line
0.57
cell type or tissue
0.47
pathway
0.35
tissue sample
0.33


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.25   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 4   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.25   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 4   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1344364
24110
Rat
RGD:1359153
312688
Dog
ubiquitin specific peptidase 18
486763
Horse
ubiquitin specific peptidase 18
100054488
Cow
ubiquitin specific peptidase 18
515202
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
ubiquitin specific peptidase 18
Horse
ubiquitin specific peptidase 18
Cow
ubiquitin specific peptidase 18
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q3LFD5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cytokine Signaling in Immune system
Reactome
ISG15 antiviral mechanism
Reactome
Immune System
Reactome
Interferon Signaling
Name
Explore in Pharos
Explore in Source
Antiviral mechanism by IFN-stimulated genes
Cytokine Signaling in Immune system
ISG15 antiviral mechanism
Immune System
Interferon Signaling
Protein-Protein Interactions (50)
1 – 10 of 50
USP18
Tbio
Family: Enzyme
Novelty: 0.01087689
p_int: 1
Score: 0.709
Data Source: BioPlex,STRINGDB
ISG15
Tbio
Novelty: 0.00203781
Score: 0.989
Data Source: STRINGDB
MX2
Tbio
Novelty: 0.00139073
Score: 0.959
Data Source: STRINGDB
MX1
Tbio
Novelty: 0.00072554
Score: 0.959
Data Source: STRINGDB
IFIT1
Tbio
Novelty: 0.00562299
Score: 0.954
Data Source: STRINGDB
DDX58
Tbio
Family: Enzyme
Novelty: 0.00080099
Score: 0.944
Data Source: STRINGDB
STAT1
Tchem
Family: TF
Novelty: 0.0003383
Score: 0.94
Data Source: STRINGDB
EIF2AK2
Tchem
Family: Kinase
Novelty: 0.00736681
Score: 0.922
Data Source: STRINGDB
UBE2E1
Tbio
Novelty: 0.04048768
Score: 0.911
Data Source: STRINGDB
JAK1
Tclin
Family: Kinase
Novelty: 0.00093625
Score: 0.91
Data Source: STRINGDB
Publication Statistics
PubMed Score  3.25

PubMed score by year
PubTator Score  0.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer