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Tbio
CHD9
Chromodomain-helicase-DNA-binding protein 9

Protein Summary
Description
Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Proposed to be a ATP-dependent chromatin remodeling protein. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000398510
  • ENSP00000381522
  • ENSG00000177200
  • ENST00000447540
  • ENSP00000396345
  • ENST00000564845
  • ENSP00000455307
  • ENST00000566029
  • ENSP00000457466

Symbol
  • KIAA0308
  • KISH2
  • PRIC320
  • AD013
  • CHD-9
  • CReMM
  • KISH2
  • PRIC320
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.98
protein domain
0.97
co-expressed gene
0.95
molecular function
0.93
transcription factor perturbation
0.91


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.42   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 55   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.42   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
3
86.1
monocyte percentage of leukocytes
2
2
2
80.6
fibrinogen measurement
4
4
4
77.3
intelligence
3
5
3
6.7
76.6
neutrophil count
2
2
2
68.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
86.1
monocyte percentage of leukocytes
2
80.6
fibrinogen measurement
4
77.3
intelligence
3
6.7
76.6
neutrophil count
2
68.5
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chromodomain helicase DNA binding protein 9
VGNC:5734
454088
Macaque
chromodomain helicase DNA binding protein 9
696367
Mouse
MGI:1924001
109151
Dog
chromodomain helicase DNA binding protein 9
VGNC:39207
478128
Horse
chromodomain helicase DNA binding protein 9
VGNC:16491
100050375
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chromodomain helicase DNA binding protein 9
Macaque
chromodomain helicase DNA binding protein 9
Mouse
Dog
chromodomain helicase DNA binding protein 9
Horse
chromodomain helicase DNA binding protein 9
Protein Structure (0 Structures, 9 AlphaFold Models)
RepresentationColor Scheme

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (15)
Activation of gene expression by SREBF (SREBP) (R-HSA-2426168)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of gene expression by SREBF (SREBP)
Reactome
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Reactome
Circadian Clock
Reactome
Developmental Biology
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Activation of gene expression by SREBF (SREBP)
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Circadian Clock
Developmental Biology
Metabolism
Gene Ontology Terms (7)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (132)
1 – 10 of 132
ANKRD36B
Tdark
Novelty:  2.44907149
p_int:  0.99999898
p_ni:  0.00000102
Data Source:  BioPlex
EPB41L5
Tbio
Novelty:  0.0391959
p_int:  0.999998956
p_ni:  0.00000104
p_wrong:  4e-9
Score:  0.691
Data Source:  BioPlex,STRINGDB
PIP4K2A
Tbio
Family:  Kinase
Novelty:  0.01130885
p_int:  0.99999654
p_ni:  0.000003439
p_wrong:  2.1e-8
Score:  0.324
Data Source:  BioPlex,STRINGDB
DAXX
Tbio
Novelty:  0.00348585
p_int:  0.999394299
p_ni:  0.000604717
p_wrong:  9.83e-7
Data Source:  BioPlex
FGF12
Tbio
Novelty:  0.02094849
p_int:  0.99909962
p_ni:  0.000900351
p_wrong:  2.9e-8
Data Source:  BioPlex
EPB41L3
Tbio
Novelty:  0.00915217
p_int:  0.99866741
p_ni:  0.001332376
p_wrong:  2.14e-7
Data Source:  BioPlex
NKAP
Tbio
Novelty:  0.04982584
p_int:  0.998073595
p_ni:  0.001878701
p_wrong:  0.000047704
Score:  0.764
Data Source:  BioPlex,STRINGDB
MDK
Tchem
Novelty:  0.00145301
p_int:  0.996497911
p_ni:  0.003496929
p_wrong:  0.000005159
Score:  0.71
Data Source:  BioPlex,STRINGDB
CAMKV
Tbio
Family:  Kinase
Novelty:  0.17794181
p_int:  0.977172019
p_ni:  0.022822848
p_wrong:  0.000005133
Score:  0.291
Data Source:  BioPlex,STRINGDB
HELZ2
Tdark
Family:  Enzyme
Novelty:  0.1810765
Score:  0.952
Data Source:  STRINGDB
Publication Statistics
PubMed Score  18.42

PubMed score by year
PubTator Score  7.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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