Tbio CHD9 Chromodomain-helicase-DNA-binding protein 9

Protein Summary

Description

Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Proposed to be a ATP-dependent chromatin remodeling protein. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity).

Uniprot Accession IDs

• Q3L8U1
• B2RTU2
• B9ZVQ0
• O15025
• Q1WF12
• Q6DTK9
• Q9H9V7
• Q9UHM2
• CHD-9

Gene Name

• CHD9

Ensembl ID

• ENST00000398510
• ENSP00000381522
• ENSG00000177200
• ENST00000447540
• ENSP00000396345
• ENST00000564845
• ENSP00000455307
• ENST00000566029
• ENSP00000457466

Symbol

• KIAA0308
• KISH2
• PRIC320
• AD013
• CHD-9
• CReMM
• KISH2
• PRIC320

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.98
protein domain	0.97
co-expressed gene	0.95
molecular function	0.93
transcription factor perturbation	0.91

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.01   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 55   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.01   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0