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Tbio
ARHGAP11B
Rho GTPase-activating protein 11B

Protein Summary
Description
Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex (PubMed:25721503). Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis (PubMed:25721503). Does not possess GTPase activator activity (PubMed:25721503).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000428041
  • ENSP00000392760
  • ENSG00000285077
  • ENST00000621228
  • ENSP00000482099
  • ENSG00000274734

Symbol
  • FAM7B1
  • B'-T
  • FAM7B1
  • GAP (1-8)
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.5
cell line
0.48
transcription factor binding site profile
0.41
cell type or tissue
0.38
histone modification site profile
0.38


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.76   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 35   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.76   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 35   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0