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Tbio
GRAMD1B
Protein Aster-B

Protein Summary
Description
Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000450171
  • ENSP00000388458
  • ENSG00000023171
  • ENST00000456860
  • ENSP00000402457
  • ENST00000529432
  • ENSP00000432987
  • ENST00000529750
  • ENSP00000436500

Symbol
  • KIAA1201
  • LINC01059
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.68
gene perturbation
0.57
PubMedID
0.55
phenotype
0.54
cell type or tissue
0.53


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.77   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 60   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.77   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 60   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
3
0
1.6
96.4
serum IgM measurement
2
2
2
87.5
testosterone measurement
4
3
4
85.6
lymphocyte count
2
1
2
68.6
lymphoid leukemia
1
1
0
1.5
61
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.6
96.4
serum IgM measurement
2
87.5
testosterone measurement
4
85.6
lymphocyte count
2
68.6
lymphoid leukemia
0
1.5
61
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GRAM domain containing 1B
VGNC:3117
451632
Macaque
GRAM domain containing 1B
708497
Mouse
MGI:1925037
235283
Rat
RGD:1305443
300644
Dog
GRAM domain containing 1B
VGNC:41466
489352
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GRAM domain containing 1B
Macaque
GRAM domain containing 1B
Mouse
Rat
Dog
GRAM domain containing 1B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q3KR37-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (11)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (36)
1 – 10 of 36
GRAMD2B
Tdark
Novelty:  0.55744753
p_int:  0.999999631
p_ni:  3.67e-7
p_wrong:  2e-9
Score:  0.69
Data Source:  BioPlex,STRINGDB
GRAMD1C
Tdark
Novelty:  0.46102163
p_int:  0.99999859
p_ni:  0.000001395
p_wrong:  1.5e-8
Score:  0.686
Data Source:  BioPlex,STRINGDB
LSMEM2
Tdark
Novelty:  43
p_int:  0.999995054
p_ni:  0.000004944
p_wrong:  2e-9
Data Source:  BioPlex
ZBTB1
Tbio
Family:  TF
Novelty:  0.33667235
p_int:  0.999927542
p_ni:  0.000072451
p_wrong:  7e-9
Score:  0.19
Data Source:  BioPlex,STRINGDB
GRAMD1A
Tbio
Novelty:  0.15461113
p_int:  0.999890565
p_ni:  0.000109435
Score:  0.744
Data Source:  BioPlex,STRINGDB
GTPBP2
Tbio
Novelty:  0.10282876
p_int:  0.999828639
p_ni:  0.000171361
Data Source:  BioPlex
PDCD2L
Tbio
Novelty:  0.33193498
p_int:  0.999820206
p_ni:  0.00017979
p_wrong:  5e-9
Data Source:  BioPlex
PCDHGB4
Tdark
Novelty:  0.25018904
p_int:  0.999705759
p_ni:  0.000294201
p_wrong:  4e-8
Data Source:  BioPlex
C7orf43
Tdark
Novelty:  1.11975505
p_int:  0.999501871
p_ni:  0.000498129
Data Source:  BioPlex
CEP55
Tbio
Novelty:  0.01328073
p_int:  0.999319858
p_ni:  0.000680142
Data Source:  BioPlex
Publication Statistics
PubMed Score  5.77

PubMed score by year
PubTator Score  1.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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