Tbio PLEKHG6 Pleckstrin homology domain-containing family G member 6

Protein Summary

Description

Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis.

Uniprot Accession IDs

• Q3KR16
• Q3SWR1
• Q8N1P1
• Q8WYY1
• Q9H8F4
• Q9NVK9
• PH domain-containing family G member 6

Gene Name

• PLEKHG6

Ensembl ID

• ENST00000011684
• ENSP00000011684
• ENSG00000008323
• ENST00000304581
• ENSP00000304640
• ENST00000396988
• ENSP00000380185
• ENST00000449001
• ENSP00000393194

Symbol

• MyoGEF

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor	0.68
protein domain	0.58
small molecule perturbation	0.52
cellular component	0.49
PubMedID	0.48

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.68   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 128   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.68   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0