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Tdark
SLC10A6
Solute carrier family 10 member 6

Protein Summary
Description
Transports sulfoconjugated steroid hormones, as well as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes in a sodium-dependent manner.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273905
  • ENSP00000273905
  • ENSG00000145283

Symbol
  • SOAT
  • SOAT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
cell type or tissue
0.8
tissue sample
0.74
tissue
0.54
metabolite
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.01   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 40   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.01   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 40   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (10)
SLC10A7
Tbio
Family:  Transporter
Novelty:  0.15556211
Score:  0.712
Data Source:  STRINGDB
SLC35F2
Tbio
Family:  Transporter
Novelty:  0.08323418
Score:  0.485
Data Source:  STRINGDB
SLC15A5
Tdark
Family:  Transporter
Novelty:  0.59784242
Score:  0.48
Data Source:  STRINGDB
SULT2A1
Tbio
Family:  Enzyme
Novelty:  0.00475549
Score:  0.465
Data Source:  STRINGDB
MFSD5
Tdark
Novelty:  0.58146966
Score:  0.447
Data Source:  STRINGDB
MFSD9
Tdark
Novelty:  0.98582986
Score:  0.441
Data Source:  STRINGDB
SLCO1B7
Tdark
Family:  Transporter
Novelty:  0.48557976
Score:  0.433
Data Source:  STRINGDB
SLC7A14
Tbio
Family:  Transporter
Novelty:  0.1613451
Score:  0.427
Data Source:  STRINGDB
CTRL
Tchem
Family:  Enzyme
Novelty:  0.00045495
Score:  0.426
Data Source:  STRINGDB
SLC22A9
Tbio
Family:  Transporter
Novelty:  0.02212992
Score:  0.402
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
SLC-mediated transmembrane transport (R-HSA-425407)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of bile salts and organic acids, metal ions and amine compounds
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
SLC-mediated transmembrane transport
Transport of bile salts and organic acids, metal ions and amine compounds
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
2
2
2
74.4
high density lipoprotein cholesterol measurement
1
1
1
50.6
1
1
0
1.1
50.6
intraocular pressure measurement
1
2
2
47.7
lymphocyte percentage of leukocytes
1
1
1
9.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
2
74.4
high density lipoprotein cholesterol measurement
1
50.6
0
1.1
50.6
intraocular pressure measurement
2
47.7
lymphocyte percentage of leukocytes
1
9.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 10 member 6
VGNC:7726
471244
Macaque
solute carrier family 10 member 6
703946
Mouse
MGI:1923000
75750
Rat
RGD:727800
289459
Dog
solute carrier family 10 member 6
VGNC:46214
609030
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 10 member 6
Macaque
solute carrier family 10 member 6
Mouse
Rat
Dog
solute carrier family 10 member 6
Publication Statistics
PubMed Score 13.01
PubMed score by year
PubTator Score 10.27
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title