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Tbio
BSX
Brain-specific homeobox protein homolog

Protein Summary
Description
DNA binding protein that function as transcriptional activator. Is essential for normal postnatal growth and nursing. Is an essential factor for neuronal neuropeptide Y and agouti-related peptide function and locomotory behavior in the control of energy balance (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343035
  • ENSP00000344285
  • ENSG00000188909

Symbol
  • BSX1
  • BSX1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.74
cell type or tissue
0.65
protein domain
0.58
biological process
0.57
cell line
0.47


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.6   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 90   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.6   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
AGRP
Tbio
Novelty:  0.00147804
Score:  0.74
Data Source:  STRINGDB
SOX5
Tbio
Family:  TF
Novelty:  0.00623121
Score:  0.669
Data Source:  STRINGDB
SOX6
Tbio
Family:  TF
Novelty:  0.00484243
Score:  0.659
Data Source:  STRINGDB
NEUROG1
Tbio
Family:  TF
Novelty:  0.00494095
Score:  0.652
Data Source:  STRINGDB
UBR1
Tbio
Family:  Enzyme
Novelty:  0.00998888
Score:  0.647
Data Source:  STRINGDB
NRGN
Tbio
Novelty:  0.00352757
Score:  0.641
Data Source:  STRINGDB
SOX3
Tbio
Family:  TF
Novelty:  0.00280653
Score:  0.629
Data Source:  STRINGDB
ITPKA
Tchem
Family:  Kinase
Novelty:  0.02901348
Score:  0.62
Data Source:  STRINGDB
SPTSSB
Tdark
Family:  Enzyme
Novelty:  0.05967882
Score:  0.605
Data Source:  STRINGDB
FOXD3
Tbio
Family:  TF
Novelty:  0.00550321
Score:  0.574
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
3
4
92.2
age at menarche
4
4
3
2.7
91.7
testosterone measurement
4
1
4
81.9
mean corpuscular hemoglobin concentration
3
2
3
81.3
puberty onset measurement
3
1
3
79.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
92.2
age at menarche
3
2.7
91.7
testosterone measurement
4
81.9
mean corpuscular hemoglobin concentration
3
81.3
puberty onset measurement
3
79.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
brain specific homeobox
VGNC:3199
466808
Mouse
MGI:2669849
244813
Rat
RGD:1565120
500982
Dog
brain specific homeobox
VGNC:38543
489354
Horse
brain specific homeobox
VGNC:15906
100071656
Species
Name
OMA
EggNOG
Inparanoid
Chimp
brain specific homeobox
Mouse
Rat
Dog
brain specific homeobox
Horse
brain specific homeobox
Publication Statistics
PubMed Score 74.60
PubMed score by year
PubTator Score 11.55
PubTator score by year
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Related Publications
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PMID
Year
Title