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Tbio
PROX2
Prospero homeobox protein 2

Protein Summary
Description
Transcription regulator. Does not seem to be essential for embryonic development and postnatal survival (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000556084
  • ENSP00000451463
  • ENSG00000119608

Symbol
  • PROX-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.82
tissue sample
0.56
cell line
0.53
biological process
0.44
tissue
0.42


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.36   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.36   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
3
3
1
7.3
93
worry measurement
2
3
2
6
88.3
depressive symptom measurement
1
1
1
57.4
parental longevity
1
1
1
19.6
feeling "fed-up" measurement
1
1
0
6
2.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
1
7.3
93
worry measurement
2
6
88.3
depressive symptom measurement
1
57.4
parental longevity
1
19.6
feeling "fed-up" measurement
0
6
2.9
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1920672
73422
Rat
RGD:1310315
314319
Dog
prospero homeobox 2
VGNC:45018
100855765
Cow
prospero homeobox 2
VGNC:33370
529720
Pig
prospero homeobox 2
100155976
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
prospero homeobox 2
Cow
prospero homeobox 2
Pig
prospero homeobox 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q3B8N5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (25)
1 – 10 of 25
VRTN
Tdark
Novelty: 0.07572815
Score: 0.753
Data Source: STRINGDB
ARMC4
Tbio
Novelty: 0.17860406
Score: 0.677
Data Source: STRINGDB
LMAN2
Tbio
Novelty: 0.02922729
Score: 0.65
Data Source: STRINGDB
SULT4A1
Tbio
Family: Enzyme
Novelty: 0.02455678
Score: 0.642
Data Source: STRINGDB
AREL1
Tdark
Family: Enzyme
Novelty: 0.31082841
Score: 0.622
Data Source: STRINGDB
SYNDIG1L
Tdark
Novelty: 0.13042909
Score: 0.603
Data Source: STRINGDB
YLPM1
Tdark
Novelty: 0.26435727
Score: 0.596
Data Source: STRINGDB
ALX3
Tbio
Family: TF
Novelty: 0.02711914
Score: 0.557
Data Source: STRINGDB
ANGPTL1
Tbio
Novelty: 0.03123564
Score: 0.55
Data Source: STRINGDB
TMEM165
Tbio
Novelty: 0.03344104
Score: 0.545
Data Source: STRINGDB
Publication Statistics
PubMed Score  9.36

PubMed score by year
PubTator Score  1.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer