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Tdark
TWISTNB
DNA-directed RNA polymerase I subunit RPA43

Protein Summary
Description
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Through its association with RRN3/TIF-IA may be involved in recruitment of Pol I to rDNA promoters.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222567
  • ENSP00000222567
  • ENSG00000105849
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.88
ligand (protein) perturbation
0.83
virus perturbation
0.83
cellular component
0.82
kinase perturbation
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.69   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 85   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.69   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 85   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (368)
1 – 10 of 368
RRN3
Tbio
Family:  Enzyme
Novelty:  0.01643149
p_int:  0.999839024
p_ni:  0.000160972
p_wrong:  4e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
POLR1C
Tbio
Family:  Enzyme
Novelty:  0.04485332
p_int:  0.955979696
p_ni:  0.044020304
Score:  0.999
Data Source:  BioPlex,STRINGDB
POLR1A
Tchem
Family:  Enzyme
Novelty:  0.0485107
p_int:  0.941095799
p_ni:  0.058904201
Score:  0.999
Data Source:  BioPlex,STRINGDB
ZNF23
Tbio
Family:  TF
Novelty:  0.33673708
p_int:  0.904937874
p_ni:  0.093561376
p_wrong:  0.001500749
Data Source:  BioPlex
POLR1B
Tbio
Family:  Enzyme
Novelty:  0.06955307
p_int:  0.904795977
p_ni:  0.095204023
Score:  0.999
Data Source:  BioPlex,STRINGDB
SLC13A2
Tbio
Family:  Transporter
Novelty:  0.01020451
p_int:  0.863301043
p_ni:  0.136698897
p_wrong:  6e-8
Score:  0.205
Data Source:  BioPlex,STRINGDB
TGM5
Tbio
Family:  Enzyme
Novelty:  0.01209333
p_int:  0.804811258
p_ni:  0.192956583
p_wrong:  0.002232159
Score:  0.189
Data Source:  BioPlex,STRINGDB
NOLC1
Tbio
Novelty:  0.01922261
p_int:  0.804106738
p_ni:  0.195893208
p_wrong:  5.3e-8
Score:  0.874
Data Source:  BioPlex,STRINGDB
POLR1D
Tbio
Novelty:  0.01598347
Score:  0.999
Data Source:  STRINGDB
POLR1D
Tbio
Family:  Enzyme
Novelty:  0.01598347
Score:  0.999
Data Source:  STRINGDB
Pathways (13)
B-WICH complex positively regulates rRNA expression (R-HSA-5250924)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
B-WICH complex positively regulates rRNA expression
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Reactome
Negative epigenetic regulation of rRNA expression
Reactome
NoRC negatively regulates rRNA expression
Name
Explore in Pharos
Explore in Source
B-WICH complex positively regulates rRNA expression
Epigenetic regulation of gene expression
Gene expression (Transcription)
Negative epigenetic regulation of rRNA expression
NoRC negatively regulates rRNA expression
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
29
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TWIST neighbor
VGNC:4554
463911
Macaque
TWIST neighbor
707781
Mouse
MGI:106292
28071
Rat
RGD:1307824
362728
Dog
TWIST neighbor
610923
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TWIST neighbor
Macaque
TWIST neighbor
Mouse
Rat
Dog
TWIST neighbor
Publication Statistics
PubMed Score 1.69
PubMed score by year
PubTator Score 1.45
PubTator score by year