Tdark TWISTNB DNA-directed RNA polymerase I subunit RPA43

Protein Summary

Description

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Through its association with RRN3/TIF-IA may be involved in recruitment of Pol I to rDNA promoters.

Uniprot Accession IDs

• Q3B726
• A0PJ45
• B7Z724

Gene Name

• TWISTNB

Ensembl ID

• ENST00000222567
• ENSP00000222567
• ENSG00000105849

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.88
ligand (protein) perturbation	0.83
virus perturbation	0.83
cellular component	0.82
kinase perturbation	0.81

Protein Classes

PANTHER Classes

Protein / Transferase / Nucleotidyltransferase / Dna-directed Rna Polymerase I Subunit Rpa43

Protein / Transcription Factor / Dna-directed Rna Polymerase I Subunit Rpa43

Protein / Nucleic Acid Binding / Rna Binding Protein / Dna-directed Rna Polymerase / Dna-directed Rna Polymerase I Subunit Rpa43

DTO Classes

Protein / Enzyme / Transferase / Nucleotidyltransferase / Polymerase / Dna-directed Rna Polymerase / Dna-directed Rna Polymerase I Subunit Rpa43

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.13   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 85   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.13   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 85   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0