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Tbio
LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

Protein Summary
Description
This gene encodes a multi-domain protein that is a leucine-rich repeat kinase and a GDP/GTP binding protein. The encoded protein is thought to play a role in the regulation of bone mass. Mice lacking a similar gene showed severe osteopetrosis, increased bone mineralization and decreased bone resorption. [provided by RefSeq, Jan 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000388948
  • ENSP00000373600
  • ENSG00000154237
  • ENST00000532029
  • ENSP00000433268

Symbol
  • KIAA1790
  • RIPK6
  • Roco1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
kinase perturbation
0.99
molecular function
0.97
PubMedID
0.87
transcription factor binding site profile
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.34   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 168   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.34   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
3
2
0
1692.3
88.2
corneal topography
1
1
1
79.9
balding measurement
1
1
1
47.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
0
1692.3
88.2
corneal topography
1
79.9
balding measurement
1
47.2
Gene Ontology Terms (13)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (72)
1 – 10 of 72
CDK5RAP2
Tbio
Novelty: 0.00956263
Score: 0.772
Data Source: STRINGDB
PINK1
Tbio
Family: Kinase
Novelty: 0.00100973
Score: 0.741
Data Source: STRINGDB
SFN
Tbio
Novelty: 0.00340233
Score: 0.737
Data Source: STRINGDB
PRKN
Tbio
Family: Enzyme
Novelty: 0.00079898
Score: 0.73
Data Source: STRINGDB
GTPBP4
Tbio
Novelty: 0.00062563
Score: 0.72
Data Source: STRINGDB
ADGRL1
Tbio
Family: GPCR
Novelty: 0.00957739
Score: 0.685
Data Source: STRINGDB
ADGRL2
Tbio
Family: GPCR
Novelty: 0.00985539
Score: 0.685
Data Source: STRINGDB
ADGRL3
Tbio
Family: GPCR
Novelty: 0.00268343
Score: 0.685
Data Source: STRINGDB
VPS35
Tbio
Novelty: 0.00729892
Score: 0.671
Data Source: STRINGDB
PARK7
Tbio
Family: Enzyme
Novelty: 0.00104651
Score: 0.666
Data Source: STRINGDB
Publication Statistics
PubMed Score  23.34

PubMed score by year
PubTator Score  25.95

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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