Tbio LRRK1 Leucine-rich repeat serine/threonine-protein kinase 1

Protein Summary

Description

This gene encodes a multi-domain protein that is a leucine-rich repeat kinase and a GDP/GTP binding protein. The encoded protein is thought to play a role in the regulation of bone mass. Mice lacking a similar gene showed severe osteopetrosis, increased bone mineralization and decreased bone resorption. [provided by RefSeq, Jan 2017]

Uniprot Accession IDs

• Q38SD2
• Q6NVH5
• Q6NYC0
• Q6ZNL9
• Q6ZNM9
• Q96JN5
• Q9H5S3

Gene Name

• LRRK1

Ensembl ID

• ENST00000388948
• ENSP00000373600
• ENSG00000154237
• ENST00000532029
• ENSP00000433268

Symbol

• KIAA1790
• RIPK6
• Roco1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
kinase perturbation	0.99
molecular function	0.97
PubMedID	0.87
transcription factor binding site profile	0.84

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Tkl Group / Lrrk Family / Leucine-rich Repeat Serine/threonine-protein Kinase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.58   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 168   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.58   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0