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Tdark
PLPPR5
Phospholipid phosphatase-related protein type 5

Protein Summary
Description
Induces filopodia formation and promotes neurite growth in a CDC42-independent manner; impedes neurite growth inhibitory-mediated axonal retraction. The protein encoded by this gene is a type 2 member of the phosphatidic acid phosphatase (PAP) family. All type 2 members of this protein family contain 6 transmembrane regions, and a consensus N-glycosylation site. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263177
  • ENSP00000263177
  • ENSG00000117598
  • ENST00000370188
  • ENSP00000359207

Symbol
  • LPPR5
  • PAP2D
  • PRG5
  • PAP2
  • PRG5
  • LPPR5
  • PAP2D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.09   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 112   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.09   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (15)
1 – 10 of 15
SWSAP1
Tbio
Family:  Enzyme
Novelty:  0.39530563
Score:  0.668
Data Source:  STRINGDB
SNX7
Tbio
Novelty:  0.1473151
Score:  0.665
Data Source:  STRINGDB
FAM53B
Tdark
Novelty:  0.00761169
Score:  0.599
Data Source:  STRINGDB
PALMD
Tbio
Novelty:  0.11193793
Score:  0.562
Data Source:  STRINGDB
CHCHD7
Tdark
Novelty:  0.03220354
Score:  0.517
Data Source:  STRINGDB
TMEM25
Tdark
Novelty:  0.35505784
Score:  0.514
Data Source:  STRINGDB
SCRG1
Tbio
Novelty:  0.12949928
Score:  0.493
Data Source:  STRINGDB
GART
Tclin
Novelty:  0.00524985
Score:  0.492
Data Source:  STRINGDB
GTDC1
Tbio
Family:  Enzyme
Novelty:  0.1887215
Score:  0.477
Data Source:  STRINGDB
ARHGAP25
Tbio
Family:  Enzyme
Novelty:  0.14944305
Score:  0.465
Data Source:  STRINGDB
Pathways (5)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
GPCR ligand binding
Reactome
Lysosphingolipid and LPA receptors
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
GPCR ligand binding
Lysosphingolipid and LPA receptors
Signal Transduction
Signaling by GPCR
Gene Ontology Terms (9)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
1
0
1.1
17.8
smoking behavior
1
1
1
17.8
mathematical ability
1
1
1
2.7
smoking behaviour measurement
1
1
1
1.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
0
1.1
17.8
smoking behavior
1
17.8
mathematical ability
1
2.7
smoking behaviour measurement
1
1.2
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phospholipid phosphatase related 5
VGNC:11780
457049
Macaque
phospholipid phosphatase related 5
710549
Mouse
MGI:1923019
75769
Horse
phospholipid phosphatase related 5
VGNC:50862
100056696
Pig
phospholipid phosphatase related 5
100514836
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phospholipid phosphatase related 5
Macaque
phospholipid phosphatase related 5
Mouse
Horse
phospholipid phosphatase related 5
Pig
phospholipid phosphatase related 5
Publication Statistics
PubMed Score 4.09
PubMed score by year
PubTator Score 5.25
PubTator score by year