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Tbio
TRMT5
tRNA (guanine(37)-N1)-methyltransferase

Protein Summary
Description
Involved in mitochondrial tRNA methylation (PubMed:26189817). Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. tRNAs contain as many as 13 or 14 nucleotides that are modified posttranscriptionally by enzymes that are highly specific for particular nucleotides in the tRNA structure. TRMT5 methylates the N1 position of guanosine-37 (G37) in selected tRNAs using S-adenosyl methionine (Brule et al., 2004 [PubMed 15248782]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261249
  • ENSP00000261249
  • ENSG00000126814

Symbol
  • KIAA1393
  • TRM5
  • TRM5
  • COXPD26
  • KIAA1393
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
histone modification site profile
0.91
kinase perturbation
0.91
cellular component
0.65
small molecule perturbation
0.64


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.6   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 61   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.6   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 61   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tRNA methyltransferase 5
VGNC:3295
467474
Macaque
tRNA methyltransferase 5 [Source:HGNC Symbol;Acc:HGNC:23141]
Mouse
MGI:1923607
76357
Rat
RGD:1306567
362754
Dog
tRNA methyltransferase 5
VGNC:47859
480347
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tRNA methyltransferase 5
Macaque
tRNA methyltransferase 5 [Source:HGNC Symbol;Acc:HGNC:23141]
Mouse
Rat
Dog
tRNA methyltransferase 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q32P41-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Synthesis of wybutosine at G37 of tRNA(Phe)
Reactome
tRNA modification in the nucleus and cytosol
Reactome
tRNA processing
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Synthesis of wybutosine at G37 of tRNA(Phe)
tRNA modification in the nucleus and cytosol
tRNA processing
Protein-Protein Interactions (107)
1 – 10 of 107
HSP90AA4P
Tdark
p_int:  0.793735829
p_ni:  0.206203148
p_wrong:  0.000061023
Data Source:  BioPlex
PCBP3
Tbio
Novelty:  0.11681812
p_int:  0.780383567
p_ni:  0.219616375
p_wrong:  5.8e-8
Data Source:  BioPlex
TYW3
Tdark
Novelty:  0.15183348
Score:  0.928
Data Source:  STRINGDB
TRMT12
Tbio
Family:  Enzyme
Novelty:  0.12417204
Score:  0.92
Data Source:  STRINGDB
TYW1
Tbio
Family:  Enzyme
Novelty:  0.05117274
Score:  0.908
Data Source:  STRINGDB
TRMT10A
Tbio
Family:  Enzyme
Novelty:  0.04694256
Score:  0.904
Data Source:  STRINGDB
LCMT2
Tbio
Family:  Enzyme
Novelty:  0.0388779
Score:  0.887
Data Source:  STRINGDB
FTSJ1
Tbio
Family:  Enzyme
Novelty:  0.01511808
Score:  0.853
Data Source:  STRINGDB
TRMT1
Tbio
Family:  Enzyme
Novelty:  0.01795504
Score:  0.851
Data Source:  STRINGDB
TRMT61A
Tbio
Family:  Enzyme
Novelty:  0.04443394
Score:  0.847
Data Source:  STRINGDB
Publication Statistics
PubMed Score  42.60

PubMed score by year
PubTator Score  15.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer