Tbio P3H1 Prolyl 3-hydroxylase 1

Protein Summary

Description

Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts. This gene encodes an enzyme that is a member of the collagen prolyl hydroxylase family. These enzymes are localized to the endoplasmic reticulum and their activity is required for proper collagen synthesis and assembly. Mutations in this gene are associated with osteogenesis imperfecta type VIII. Three alternatively spliced transcript variants encoding different isoforms have been described. Other variants may exist, but their biological validity has not been determined. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• Q32P28
• Q7KZR4
• Q96BR8
• Q96SK8
• Q96SL5
• Q96SN3
• Q9H6K3
• Q9HC86
• Q9HC87

Gene Name

• P3H1

Ensembl ID

• ENST00000236040
• ENSP00000236040
• ENSG00000117385
• ENST00000296388
• ENSP00000296388
• ENST00000397054
• ENSP00000380245

Symbol

• GROS1
• LEPRE1
• OI8
• GROS1
• LEPRE1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.9
transcription factor perturbation	0.84
histone modification site profile	0.81
cellular component	0.8
interacting protein	0.69

Protein Classes

PANTHER Classes

Protein / Extracellular Matrix Protein / Extracellular Matrix Glycoprotein / Prolyl 3-hydroxylase 1

DTO Classes

Protein / Extracellular Structure / Extracellular Matrix Glycoprotein / Prolyl 3-hydroxylase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.24   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 260   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.24   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 260   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0