Tbio LRRFIP1 Leucine-rich repeat flightless-interacting protein 1

Protein Summary

Description

Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.

Uniprot Accession IDs

• Q32MZ4
• E9PGZ2
• O75766
• O75799
• Q32MZ5
• Q53T49
• Q6PKG2
• Q9Y607
• LRR FLII-interacting protein 1

Gene Name

• LRRFIP1

Ensembl ID

• ENST00000244815
• ENSP00000244815
• ENSG00000124831
• ENST00000289175
• ENSP00000289175
• ENST00000308482
• ENSP00000310109
• ENST00000392000
• ENSP00000375857

Symbol

• GCF2
• TRIP
• GCF2
• TRIP
• FLAP1
• GCF-2
• FLAP-1
• HUFI-1
• FLIIAP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	1
transcription factor perturbation	0.99
disease perturbation	0.97
PubMedID	0.94
microRNA	0.92

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Leucine-rich Repeat Flightless-interacting Protein 1

Protein / Nucleic Acid Binding / Rna Binding Protein / Leucine-rich Repeat Flightless-interacting Protein 1

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Leucine-rich Repeat Flightless-interacting Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.56   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 307   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.56   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 307   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (80)

Explore Interacting Targets

1 – 10 of 80

• See Interactions on String-DB

TMOD3

Tbio

Novelty:  0.04744699

p_int:  0.999999728

p_ni:  2.72e-7

Score:  0.237

Data Source:  BioPlex,STRINGDB

TMOD1

Tbio

Novelty:  0.01142927

p_int:  0.999999151

p_ni:  8.49e-7

Score:  0.696

Data Source:  BioPlex,STRINGDB

FLII

Tbio

Novelty:  0.00200219

p_int:  0.999915339

p_ni:  0.000084661

Score:  0.979

Data Source:  BioPlex,STRINGDB

TMOD4

Tbio

Novelty:  0.00932697

p_int:  0.999847692

p_ni:  0.000152308

Score:  0.589

Data Source:  BioPlex,STRINGDB

TFR2

Tbio

Family:  Enzyme

Novelty:  0.00480264

p_int:  0.999220004

p_ni:  0.000779996

Score:  0.232

Data Source:  BioPlex,STRINGDB

CCNB1

Tchem

Novelty:  0.0005503

p_int:  0.98040211

p_ni:  0.019597741

p_wrong:  1.49e-7

Score:  0.54

Data Source:  BioPlex,STRINGDB

IFT74

Tbio

Novelty:  0.07195266

p_int:  0.976990129

p_ni:  0.023009871

Data Source:  BioPlex

TCEAL2

Tdark

Novelty:  0.2679989

p_int:  0.953296246

p_ni:  2.14e-7

p_wrong:  0.04670354

Score:  0.282

Data Source:  BioPlex,STRINGDB

GAS2L1

Tbio

Novelty:  0.17484834

p_int:  0.878873436

p_ni:  0.121126564

Score:  0.405

Data Source:  BioPlex,STRINGDB

MCTS1

Tbio

Novelty:  0.07039427

p_int:  0.861703645

p_ni:  0.138291658

p_wrong:  0.000004697

Score:  0.19

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (10)

Reactome (10)

Cytosolic sensors of pathogen-associated DNA (R-HSA-1834949)

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5

1 – 5 of 10

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytosolic sensors of pathogen-associated DNA	64 targets	R-HSA-1834949
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	Diseases of signal transduction	387 targets	R-HSA-5663202
Reactome	FGFR1 mutant receptor activation	32 targets	R-HSA-1839124
Reactome	Immune System	2246 targets	R-HSA-168256

Name	Explore in Pharos	Explore in Source
Cytosolic sensors of pathogen-associated DNA	64 targets	R-HSA-1834949
Disease	1105 targets	R-HSA-1643685
Diseases of signal transduction	387 targets	R-HSA-5663202
FGFR1 mutant receptor activation	32 targets	R-HSA-1839124
Immune System	2246 targets	R-HSA-168256

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (17)

Functions (7)

Components (5)

Processes (5)

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Items per page:

10

1 – 7 of 7

GO Term	Evidence	Assigned by
DNA binding	Inferred from Direct Assay (IDA)	UniProtKB
protein homodimerization activity	Inferred from Direct Assay (IDA)	UniProtKB
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific	Inferred from Direct Assay (IDA)	NTNU_SB
RNA polymerase II proximal promoter sequence-specific DNA binding	Inferred from Direct Assay (IDA)	NTNU_SB
cadherin binding	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
double-stranded RNA binding	Traceable Author Statement (TAS)	ProtInc

Disease Associations ()

No disease associations found

GWAS Traits (3)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	1	1	1		58.4
prostate carcinoma	EFO_0001663	2	1	0	1.1	47.7
apolipoprotein A 1 measurement	EFO_0004614	1	1	1		24.5

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	1		58.4
prostate carcinoma	EFO_0001663	0	1.1	47.7
apolipoprotein A 1 measurement	EFO_0004614	1		24.5

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Coiled coil
Complete proteome
Cytoplasm
DNA-binding
Isopeptide bond
Nucleus
Phosphoprotein

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein A 1 measurement
mean platelet volume
prostate carcinoma

MGI Phenotype Find Similar Targets

No Header	No Header
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (3)

1 – 3 of 3

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	LRR binding FLII interacting protein 1		704379
Mouse	leucine rich repeat (in FLII) interacting protein 1	MGI:1342770	16978
Rat	LRR binding FLII interacting protein 1	RGD:1359548	367314

Species	Name	OMA	EggNOG	Inparanoid
Macaque	LRR binding FLII interacting protein 1
Mouse	leucine rich repeat (in FLII) interacting protein 1
Rat	LRR binding FLII interacting protein 1

Publication Statistics

PubMed Score 42.56

PubMed score by year

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PubTator Score 53.64

PubTator score by year

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Related Publications

Text Mined References (29)

GeneRif Annotations (13)

Items per page:

10

0 of 0

PMID	Year	Title