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Tbio
LRRFIP1
Leucine-rich repeat flightless-interacting protein 1

Protein Summary
Description
Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244815
  • ENSP00000244815
  • ENSG00000124831
  • ENST00000289175
  • ENSP00000289175
  • ENST00000308482
  • ENSP00000310109
  • ENST00000392000
  • ENSP00000375857

Symbol
  • GCF2
  • TRIP
  • GCF2
  • TRIP
  • FLAP1
  • GCF-2
  • FLAP-1
  • HUFI-1
  • FLIIAP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
transcription factor perturbation
0.99
disease perturbation
0.97
PubMedID
0.94
microRNA
0.92


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.72   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 307   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.72   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 307   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
61.2
apolipoprotein A 1 measurement
1
1
1
11.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
61.2
apolipoprotein A 1 measurement
1
11.3
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
LRR binding FLII interacting protein 1
704379
Mouse
MGI:1342770
16978
Rat
RGD:1359548
367314
Species
Name
OMA
EggNOG
Inparanoid
Macaque
LRR binding FLII interacting protein 1
Mouse
Rat
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q32MZ4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
Cytosolic sensors of pathogen-associated DNA (R-HSA-1834949)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic sensors of pathogen-associated DNA
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
FGFR1 mutant receptor activation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytosolic sensors of pathogen-associated DNA
Disease
Diseases of signal transduction
FGFR1 mutant receptor activation
Immune System
Gene Ontology Terms (17)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (80)
1 – 10 of 80
TMOD3
Tbio
Novelty: 0.04744699
p_int: 0.999999728
p_ni: 2.72e-7
Score: 0.237
Data Source: BioPlex,STRINGDB
TMOD1
Tbio
Novelty: 0.01142927
p_int: 0.999999151
p_ni: 8.49e-7
Score: 0.696
Data Source: BioPlex,STRINGDB
FLII
Tbio
Novelty: 0.00200219
p_int: 0.999915339
p_ni: 0.000084661
Score: 0.979
Data Source: BioPlex,STRINGDB
TMOD4
Tbio
Novelty: 0.00932697
p_int: 0.999847692
p_ni: 0.000152308
Score: 0.589
Data Source: BioPlex,STRINGDB
TFR2
Tbio
Family: Enzyme
Novelty: 0.00480264
p_int: 0.999220004
p_ni: 0.000779996
Score: 0.232
Data Source: BioPlex,STRINGDB
CCNB1
Tchem
Novelty: 0.0005503
p_int: 0.98040211
p_ni: 0.019597741
p_wrong: 1.49e-7
Score: 0.54
Data Source: BioPlex,STRINGDB
IFT74
Tbio
Novelty: 0.07195266
p_int: 0.976990129
p_ni: 0.023009871
Data Source: BioPlex
TCEAL2
Tdark
Novelty: 0.2679989
p_int: 0.953296246
p_ni: 2.14e-7
p_wrong: 0.04670354
Score: 0.282
Data Source: BioPlex,STRINGDB
GAS2L1
Tbio
Novelty: 0.17484834
p_int: 0.878873436
p_ni: 0.121126564
Score: 0.405
Data Source: BioPlex,STRINGDB
MCTS1
Tbio
Novelty: 0.07039427
p_int: 0.861703645
p_ni: 0.138291658
p_wrong: 0.000004697
Score: 0.19
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  41.72

PubMed score by year
PubTator Score  53.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer