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Tbio
LRRFIP1
Leucine-rich repeat flightless-interacting protein 1

Protein Summary
Description
Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244815
  • ENSP00000244815
  • ENSG00000124831
  • ENST00000289175
  • ENSP00000289175
  • ENST00000308482
  • ENSP00000310109
  • ENST00000392000
  • ENSP00000375857

Symbol
  • GCF2
  • TRIP
  • GCF2
  • TRIP
  • FLAP1
  • GCF-2
  • FLAP-1
  • HUFI-1
  • FLIIAP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
transcription factor perturbation
0.99
disease perturbation
0.97
PubMedID
0.94
microRNA
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.89   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 307   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.89   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 307   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0