LRRFIP1
Leucine-rich repeat flightless-interacting protein 1
Protein Summary
Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.
- ENST00000244815
- ENSP00000244815
- ENSG00000124831
- ENST00000289175
- ENSP00000289175
- ENST00000308482
- ENSP00000310109
- ENST00000392000
- ENSP00000375857
- GCF2
- TRIP
- GCF2
- TRIP
- FLAP1
- GCF-2
- FLAP-1
- HUFI-1
- FLIIAP1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug perturbation | 1 | ||
transcription factor perturbation | 0.99 | ||
disease perturbation | 0.97 | ||
PubMedID | 0.94 | ||
microRNA | 0.92 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 50.89 (req: < 5)
Gene RIFs: 15 (req: <= 3)
Antibodies: 307 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 50.89 (req: >= 5)
Gene RIFs: 15 (req: > 3)
Antibodies: 307 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0