Tbio LRRFIP1 Leucine-rich repeat flightless-interacting protein 1

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Leucine-rich Repeat Flightless-interacting Protein 1

Protein / Nucleic Acid Binding / Rna Binding Protein / Leucine-rich Repeat Flightless-interacting Protein 1

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Leucine-rich Repeat Flightless-interacting Protein 1

Protein Summary

Description

Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.

Uniprot Accession IDs

• Q32MZ4
• E9PGZ2
• O75766
• O75799
• Q32MZ5
• Q53T49
• Q6PKG2
• Q9Y607
• LRR FLII-interacting protein 1

Gene Name

• LRRFIP1

Ensembl ID

• ENST00000244815
• ENSP00000244815
• ENSG00000124831
• ENST00000289175
• ENSP00000289175
• ENST00000308482
• ENSP00000310109
• ENST00000392000
• ENSP00000375857

Symbol

• GCF2
• TRIP
• GCF2
• TRIP
• FLAP1
• GCF-2
• FLAP-1
• HUFI-1
• FLIIAP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	1
transcription factor perturbation	0.99
disease perturbation	0.97
PubMedID	0.94
microRNA	0.92

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.72   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 307   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.72   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 307   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	1	1	1		61.2
apolipoprotein A 1 measurement	EFO_0004614	1	1	1		11.3

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	1		61.2
apolipoprotein A 1 measurement	EFO_0004614	1		11.3

Reset Zoom  Beta Count   Odds Ratio

Orthologs (3)

1 – 3 of 3

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	LRR binding FLII interacting protein 1		704379
Mouse	leucine rich repeat (in FLII) interacting protein 1	MGI:1342770	16978
Rat	LRR binding FLII interacting protein 1	RGD:1359548	367314

Species	Name	OMA	EggNOG	Inparanoid
Macaque	LRR binding FLII interacting protein 1
Mouse	leucine rich repeat (in FLII) interacting protein 1
Rat	LRR binding FLII interacting protein 1

Protein Structure (1 Structure, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q32MZ4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (10)

Reactome (10)

Cytosolic sensors of pathogen-associated DNA (R-HSA-1834949)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytosolic sensors of pathogen-associated DNA	64 targets	R-HSA-1834949
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	Diseases of signal transduction	387 targets	R-HSA-5663202
Reactome	FGFR1 mutant receptor activation	32 targets	R-HSA-1839124
Reactome	Immune System	2246 targets	R-HSA-168256

Name	Explore in Pharos	Explore in Source
Cytosolic sensors of pathogen-associated DNA	64 targets	R-HSA-1834949
Disease	1105 targets	R-HSA-1643685
Diseases of signal transduction	387 targets	R-HSA-5663202
FGFR1 mutant receptor activation	32 targets	R-HSA-1839124
Immune System	2246 targets	R-HSA-168256

Gene Ontology Terms (17)

Functions (7)

Components (5)

Processes (5)

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10

1 – 7 of 7

GO Term	Evidence	Assigned by
DNA binding	Inferred from Direct Assay (IDA)	UniProtKB
protein homodimerization activity	Inferred from Direct Assay (IDA)	UniProtKB
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific	Inferred from Direct Assay (IDA)	NTNU_SB
RNA polymerase II proximal promoter sequence-specific DNA binding	Inferred from Direct Assay (IDA)	NTNU_SB
cadherin binding	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
double-stranded RNA binding	Traceable Author Statement (TAS)	ProtInc

Protein-Protein Interactions (80)

Explore Interacting Targets

1 – 10 of 80

• See Interactions on String-DB

TMOD3

Tbio

Novelty: 0.04744699

p_int: 0.999999728

p_ni: 2.72e-7

Score: 0.237

Data Source: BioPlex,STRINGDB

TMOD1

Tbio

Novelty: 0.01142927

p_int: 0.999999151

p_ni: 8.49e-7

Score: 0.696

Data Source: BioPlex,STRINGDB

FLII

Tbio

Novelty: 0.00200219

p_int: 0.999915339

p_ni: 0.000084661

Score: 0.979

Data Source: BioPlex,STRINGDB

TMOD4

Tbio

Novelty: 0.00932697

p_int: 0.999847692

p_ni: 0.000152308

Score: 0.589

Data Source: BioPlex,STRINGDB

TFR2

Tbio

Family: Enzyme

Novelty: 0.00480264

p_int: 0.999220004

p_ni: 0.000779996

Score: 0.232

Data Source: BioPlex,STRINGDB

CCNB1

Tchem

Novelty: 0.0005503

p_int: 0.98040211

p_ni: 0.019597741

p_wrong: 1.49e-7

Score: 0.54

Data Source: BioPlex,STRINGDB

IFT74

Tbio

Novelty: 0.07195266

p_int: 0.976990129

p_ni: 0.023009871

Data Source: BioPlex

TCEAL2

Tdark

Novelty: 0.2679989

p_int: 0.953296246

p_ni: 2.14e-7

p_wrong: 0.04670354

Score: 0.282

Data Source: BioPlex,STRINGDB

GAS2L1

Tbio

Novelty: 0.17484834

p_int: 0.878873436

p_ni: 0.121126564

Score: 0.405

Data Source: BioPlex,STRINGDB

MCTS1

Tbio

Novelty: 0.07039427

p_int: 0.861703645

p_ni: 0.138291658

p_wrong: 0.000004697

Score: 0.19

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  41.72

PubMed score by year

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PubTator Score  53.64

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Acetylation
Alternative splicing
Coiled coil
Complete proteome
Cytoplasm
DNA-binding
Isopeptide bond
Nucleus
Phosphoprotein

GWAS Trait Find Similar Targets

apolipoprotein A 1 measurement
mean platelet volume

MGI Phenotype Find Similar Targets

mortality/aging