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Tbio
ZNF750
Zinc finger protein 750

Protein Summary
Description
Transcription factor involved in epidermis differentiation. Required for terminal epidermal differentiation: acts downstream of p63/TP63 and activates expression of late epidermal differentiation genes. Specifically binds to the promoter of KLF4 and promotes its expression. This gene encodes a protein with a nuclear localization site and a C2H2 zinc finger domain. Mutations in this gene have been associated with seborrhea-like dermatitis with psoriasiform elements. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269394
  • ENSP00000269394
  • ENSG00000141579

Symbol
  • ZFP750
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.95
molecular function
0.79
virus perturbation
0.76
tissue sample
0.61
biological process
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.66   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 104   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.66   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (29)
TRIM28
Tbio
Family:  Epigenetic
Novelty:  0.00778381
Score:  0.9
Data Source:  STRINGDB
MPZL3
Tbio
Novelty:  0.25092947
Score:  0.797
Data Source:  STRINGDB
TBCD
Tbio
Novelty:  0.01161221
Score:  0.794
Data Source:  STRINGDB
FN3KRP
Tbio
Family:  Kinase
Novelty:  0.10259418
Score:  0.753
Data Source:  STRINGDB
B3GNTL1
Tdark
Family:  Enzyme
Novelty:  0.13396783
Score:  0.745
Data Source:  STRINGDB
KLF4
Tbio
Family:  TF
Novelty:  0.00076828
Score:  0.723
Data Source:  STRINGDB
GRHL3
Tbio
Family:  TF
Novelty:  0.01447204
Score:  0.7
Data Source:  STRINGDB
METRNL
Tbio
Novelty:  0.04179859
Score:  0.699
Data Source:  STRINGDB
TP63
Tbio
Family:  TF
Novelty:  0.00336108
Score:  0.656
Data Source:  STRINGDB
FN3K
Tbio
Family:  Kinase
Novelty:  0.02600747
Score:  0.654
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
6
12
12
99.5
red blood cell distribution width
1
1
1
58.4
hair color
1
1
0
1.1
45.7
mean platelet volume
1
1
1
38.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
12
99.5
red blood cell distribution width
1
58.4
hair color
0
1.1
45.7
mean platelet volume
1
38.2
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 750
VGNC:9807
745746
Mouse
MGI:2442210
319530
Rat
RGD:1590044
688328
Dog
zinc finger protein 750
VGNC:48810
608362
Horse
zinc finger protein 750
VGNC:25383
100056069
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 750
Mouse
Rat
Dog
zinc finger protein 750
Horse
zinc finger protein 750
Publication Statistics
PubMed Score 29.66
PubMed score by year
PubTator Score 15.78
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title