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Tchem
MYLK3
Myosin light chain kinase 3

Protein Summary
Description
Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity). Phosphorylation of cardiac myosin heavy chains (see MYH7B, MIM 609928) and light chains (see MYL2, MIM 160781) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes (Chan et al., 2008 [PubMed 18202317]).[supplied by OMIM, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394809
  • ENSP00000378288
  • ENSG00000140795
  • ENST00000536476
  • ENSP00000439297

Symbol
  • MLCK
  • MLCK
  • MLCK2
  • caMLCK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
protein domain
0.85
gene perturbation
0.76
tissue sample
0.65
biological process
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 140.98   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 246   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 140.98   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 246   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (58)
MAPK14
Tchem
Family:  Kinase
Novelty:  0.00045138
p_int:  0.999914866
p_ni:  0.000020727
p_wrong:  0.000064407
Score:  0.595
Data Source:  BioPlex,STRINGDB
MAPK12
Tchem
Family:  Kinase
Novelty:  0.00835017
p_int:  0.998311096
p_ni:  0.001661757
p_wrong:  0.000027147
Score:  0.538
Data Source:  BioPlex,STRINGDB
CALM3
Tclin
Novelty:  0.00461552
p_int:  0.947514665
p_ni:  0.052485335
Score:  0.762
Data Source:  BioPlex,STRINGDB
OBSL1
Tbio
Novelty:  0.0325947
p_int:  0.883889758
p_ni:  0.116110242
Score:  0.675
Data Source:  BioPlex,STRINGDB
MYL2
Tbio
Novelty:  0.0018887
Score:  0.976
Data Source:  STRINGDB
MYL9
Tbio
Novelty:  0.00309239
Score:  0.942
Data Source:  STRINGDB
MYL7
Tbio
Novelty:  0.00899028
Score:  0.936
Data Source:  STRINGDB
MYL12A
Tbio
Novelty:  0.00944255
Score:  0.927
Data Source:  STRINGDB
MYL12B
Tbio
Novelty:  0.00999083
Score:  0.925
Data Source:  STRINGDB
MYL10
Tdark
Novelty:  0.01378575
Score:  0.856
Data Source:  STRINGDB
Nearest Tclin Targets (3)
Explore Nearest Tclin Targets
1 – 3 of 3
CALM1
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  6
more:  2 more common pathways
CALM3
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  6
more:  2 more common pathways
CALM2
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  6
more:  2 more common pathways
Pathways (15)
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Items per page:
1 – 5 of 9
Data Source
Name
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Explore in Source
KEGG
Platelet activation
KEGG
Focal adhesion
KEGG
Oxytocin signaling pathway
KEGG
Gastric acid secretion
KEGG
Regulation of actin cytoskeleton
Name
Explore in Pharos
Explore in Source
Platelet activation
Focal adhesion
Oxytocin signaling pathway
Gastric acid secretion
Regulation of actin cytoskeleton
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
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IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myosin light chain kinase 3
VGNC:13742
465143
Macaque
myosin light chain kinase 3
716132
Mouse
MGI:2443063
213435
Rat
RGD:1305801
291926
Dog
myosin light chain kinase 3
VGNC:43551
475345
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myosin light chain kinase 3
Macaque
myosin light chain kinase 3
Mouse
Rat
Dog
myosin light chain kinase 3
Publication Statistics
PubMed Score 140.98
PubMed score by year
PubTator Score 100.98
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title