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Tbio
ANO4
Anoctamin-4

Protein Summary
Description
Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium-activated chloride channel (CaCC) activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000392977
  • ENSP00000376703
  • ENSG00000151572
  • ENST00000392979
  • ENSP00000376705
  • ENST00000570509
  • ENSP00000471431
  • ENSG00000262139
  • ENST00000573650
  • ENSP00000469449
  • ENST00000575847
  • ENSP00000470039
  • ENST00000594618
  • ENSP00000471210

Symbol
  • TMEM16D
  • TMEM16D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.73
tissue sample
0.73
virus perturbation
0.72
gene perturbation
0.68
cell type or tissue
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.59   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 86   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.59   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist circumference
1
1
1
24.5
waist-hip ratio
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist circumference
1
24.5
waist-hip ratio
1
15.8
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
anoctamin 4
695973
Mouse
MGI:2443344
320091
Dog
anoctamin 4
VGNC:37927
612164
Horse
anoctamin 4
VGNC:15353
100066706
Cow
anoctamin 4
VGNC:25953
518739
Species
Name
OMA
EggNOG
Inparanoid
Macaque
anoctamin 4
Mouse
Dog
anoctamin 4
Horse
anoctamin 4
Cow
anoctamin 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q32M45-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
Transport of small molecules
Protein-Protein Interactions (19)
1 – 10 of 19
SLC17A8
Tbio
Family:  Transporter
Novelty:  0.00647654
Score:  0.801
Data Source:  STRINGDB
ACOT7
Tbio
Family:  Enzyme
Novelty:  0.01093954
Score:  0.629
Data Source:  STRINGDB
PLSCR5
Tdark
Family:  Enzyme
Novelty:  1.58520094
Score:  0.6
Data Source:  STRINGDB
PLSCR2
Tdark
Family:  Enzyme
Novelty:  0.3663297
Score:  0.554
Data Source:  STRINGDB
PLSCR4
Tbio
Family:  Enzyme
Novelty:  0.12079798
Score:  0.552
Data Source:  STRINGDB
GAS2L3
Tbio
Novelty:  0.12695768
Score:  0.537
Data Source:  STRINGDB
SPIC
Tbio
Family:  TF
Novelty:  0.02194141
Score:  0.527
Data Source:  STRINGDB
ASCL1
Tbio
Family:  TF
Novelty:  0.00274239
Score:  0.527
Data Source:  STRINGDB
NEK5
Tchem
Family:  Kinase
Novelty:  0.18241601
Score:  0.515
Data Source:  STRINGDB
ASH2L
Tbio
Family:  Enzyme
Novelty:  0.01586766
Score:  0.469
Data Source:  STRINGDB
Publication Statistics
PubMed Score  9.59

PubMed score by year
PubTator Score  3.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer