Tdark DEFB112 Beta-defensin 112

Protein Summary

Description

Has antibacterial activity. Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. [provided by RefSeq, Oct 2014]

Uniprot Accession IDs

• Q30KQ8
• Q8NET0

Gene Name

• DEFB112

Ensembl ID

• ENST00000322246
• ENSP00000319126
• ENSG00000180872

Symbol

• DEFB12
• DEFB-12

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.46
cell line	0.45
disease	0.43
protein complex	0.4
biological term	0.33

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.24   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 64   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.24   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0