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Tdark
DEFB116
Beta-defensin 116

Protein Summary
Description
Has antibacterial activity. Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. [provided by RefSeq, Oct 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000400549
  • ENSP00000383396
  • ENSG00000215545

Symbol
  • DEFB16
  • DEFB-16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.64
gene perturbation
0.34
biological term
0.33
pathway
0.32
cell line
0.28


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.39   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 8   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.39   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 8   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (28)
DEFB112
Tdark
Novelty:  0.29597011
Score:  0.964
Data Source:  STRINGDB
DEFB118
Tbio
Novelty:  0.14992977
Score:  0.962
Data Source:  STRINGDB
DEFB125
Tdark
Novelty:  0.69005738
Score:  0.961
Data Source:  STRINGDB
DEFB129
Tdark
Novelty:  0.26809608
Score:  0.953
Data Source:  STRINGDB
DEFB115
Tdark
Novelty:  0.51464209
Score:  0.951
Data Source:  STRINGDB
DEFA3
Tbio
Novelty:  0.04840173
Score:  0.94
Data Source:  STRINGDB
DEFA4
Tbio
Novelty:  0.04566082
Score:  0.939
Data Source:  STRINGDB
DEFA5
Tbio
Novelty:  0.00863727
Score:  0.935
Data Source:  STRINGDB
DEFB126
Tbio
Novelty:  0.05538355
Score:  0.93
Data Source:  STRINGDB
DEFB1
Tbio
Novelty:  0.00144458
Score:  0.922
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Beta defensins
Reactome
Defensins
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Beta defensins
Defensins
Immune System
Innate Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
1
1
32.6
smoking behavior
1
1
1
24.5
smoking initiation
1
1
1
14.2
smoking status measurement
1
1
1
12.2
TPE interval measurement
1
1
1
2.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
32.6
smoking behavior
1
24.5
smoking initiation
1
14.2
smoking status measurement
1
12.2
TPE interval measurement
1
2.9
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
defensin beta 116
VGNC:6089
746003
Macaque
defensin beta 116
716397
Mouse
MGI:1922650
75400
Rat
RGD:1564030
641519
Dog
defensin beta 116
VGNC:39877
100683674
Species
Name
OMA
EggNOG
Inparanoid
Chimp
defensin beta 116
Macaque
defensin beta 116
Mouse
Rat
Dog
defensin beta 116
Publication Statistics
PubMed Score 0.39
PubMed score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title