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Tdark
DEFB133
Beta-defensin 133

Protein Summary
Description
Has antibacterial activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000398721
  • ENSP00000485031
  • ENSG00000214643
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.88
cell line
0.44
pathway
0.32
biological process
0.22
transcription factor
0.2


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.07   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 7   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.07   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 7   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
defensin beta 133
VGNC:2758
740528
Rat
RGD:1560245
641653
Species
Name
OMA
EggNOG
Inparanoid
Chimp
defensin beta 133
Rat
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q30KQ1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Beta defensins
Reactome
Defensins
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Beta defensins
Defensins
Immune System
Innate Immune System
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (32)
1 – 10 of 32
DEFB110
Tdark
Novelty:  0.49548192
Score:  0.91
Data Source:  STRINGDB
DEFB135
Tdark
Novelty:  2.04107063
Score:  0.908
Data Source:  STRINGDB
DEFB113
Tdark
Novelty:  0.54376643
Score:  0.907
Data Source:  STRINGDB
DEFB121
Tdark
Novelty:  2.72797456
Score:  0.907
Data Source:  STRINGDB
DEFB116
Tdark
Novelty:  2.72622256
Score:  0.906
Data Source:  STRINGDB
DEFB114
Tbio
Novelty:  0.22206668
Score:  0.905
Data Source:  STRINGDB
DEFB128
Tbio
Novelty:  0.30093411
Score:  0.905
Data Source:  STRINGDB
DEFB127
Tbio
Novelty:  0.18126756
Score:  0.905
Data Source:  STRINGDB
DEFB115
Tdark
Novelty:  0.51464209
Score:  0.905
Data Source:  STRINGDB
DEFB112
Tdark
Novelty:  0.29597011
Score:  0.904
Data Source:  STRINGDB
Publication Statistics
PubMed Score  0.07

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer