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Tdark
DEFB135
Beta-defensin 135

Protein Summary
Description
Has antibacterial activity. Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The antimicrobial protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 8p23. [provided by RefSeq, Nov 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382208
  • ENSP00000371643
  • ENSG00000205883
  • ENST00000645596
  • ENSP00000495605
  • ENSG00000285365

Symbol
  • DEFB136
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.37
biological term
0.33
pathway
0.32
cell line
0.31
disease
0.28


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.34   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 6   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.34   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 6   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
2
2
3
90.5
wellbeing measurement
1
1
1
30.9
mathematical ability
1
1
1
29
neuroticism measurement
1
1
1
21.9
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
3
90.5
wellbeing measurement
1
30.9
mathematical ability
1
29
neuroticism measurement
1
21.9
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
defensin beta 135
738168
Macaque
defensin beta 135 [Source:HGNC Symbol;Acc:HGNC:32400]
Mouse
MGI:1920920
73670
Rat
RGD:1559641
641656
Species
Name
OMA
EggNOG
Inparanoid
Chimp
defensin beta 135
Macaque
defensin beta 135 [Source:HGNC Symbol;Acc:HGNC:32400]
Mouse
Rat
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q30KP9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Beta defensins
Reactome
Defensins
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Beta defensins
Defensins
Immune System
Innate Immune System
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (34)
1 – 10 of 34
DEFB128
Tbio
Novelty: 0.30093411
Score: 0.98
Data Source: STRINGDB
DEFB124
Tbio
Novelty: 1.65330827
Score: 0.979
Data Source: STRINGDB
DEFB125
Tdark
Novelty: 0.69005738
Score: 0.979
Data Source: STRINGDB
DEFB134
Tdark
Novelty: 0.94544485
Score: 0.978
Data Source: STRINGDB
DEFB127
Tbio
Novelty: 0.18126756
Score: 0.975
Data Source: STRINGDB
DEFB121
Tdark
Novelty: 2.72797456
Score: 0.966
Data Source: STRINGDB
DEFB118
Tbio
Novelty: 0.14992977
Score: 0.956
Data Source: STRINGDB
DEFB119
Tbio
Novelty: 0.36154966
Score: 0.952
Data Source: STRINGDB
DEFB110
Tdark
Novelty: 0.49548192
Score: 0.95
Data Source: STRINGDB
DEFB126
Tbio
Novelty: 0.05538355
Score: 0.95
Data Source: STRINGDB
Publication Statistics
PubMed Score  0.34

PubMed score by year
PubTator Score  0.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer