You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
HLA-DRB5
HLA class II histocompatibility antigen, DR beta 5 chain

Protein Summary
Description
Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loa ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.96
protein domain
0.92
disease perturbation
0.87
cellular component
0.83
disease
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 453.68   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 121   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 453.68   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
1
2
85.1
1
1
0
1.1
63.3
triglyceride measurement
1
1
1
59.6
1
20
0
1.1
51.1
1
20
0
1.1
51.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
85.1
0
1.1
63.3
triglyceride measurement
1
59.6
0
1.1
51.1
0
1.1
51.1
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (120)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Costimulation by the CD28 family
Reactome
Cytokine Signaling in Immune system
Reactome
Downstream TCR signaling
Reactome
Generation of second messenger molecules
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Costimulation by the CD28 family
Cytokine Signaling in Immune system
Downstream TCR signaling
Generation of second messenger molecules
Gene Ontology Terms (16)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (319)
1 – 10 of 319
HLA-DRB1
Tbio
Novelty: 0.00240724
p_int: 0.999999828
p_ni: 7.5e-8
p_wrong: 9.8e-8
Score: 0.98
Data Source: BioPlex,STRINGDB
HLA-DRA
Tbio
Novelty: 0.0060214
p_int: 0.999899141
p_ni: 0.000004526
p_wrong: 0.000096334
Score: 0.998
Data Source: BioPlex,STRINGDB
CHEK1
Tchem
Family: Kinase
Novelty: 0.00066843
p_int: 0.924718385
p_ni: 0.075281081
p_wrong: 5.33e-7
Score: 0.211
Data Source: BioPlex,STRINGDB
HSPA5
Tchem
Novelty: 0.00043424
p_int: 0.774931012
p_ni: 0.225068988
Data Source: BioPlex
UBR3
Tbio
Family: Enzyme
Novelty: 0.14930754
p_int: 0.76266978
p_ni: 0.23733022
Score: 0.167
Data Source: BioPlex,STRINGDB
CD74
Tchem
Novelty: 0.00281228
Score: 0.987
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.98
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.98
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.98
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.98
Data Source: STRINGDB
Publication Statistics
PubMed Score  453.68

PubMed score by year
PubTator Score  45.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: