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Tbio
HLA-DRB5
HLA class II histocompatibility antigen, DR beta 5 chain

Protein Summary
Description
Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loa ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.96
protein domain
0.92
disease perturbation
0.87
cellular component
0.83
disease
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 460.03   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 121   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 460.03   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (319)
P01911
Tchem
Novelty:  0.00240724
p_int:  0.999999828
p_ni:  7.5e-8
p_wrong:  9.8e-8
Score:  0.98
Data Source:  BioPlex,STRINGDB
HLA-DRA
Tbio
Novelty:  0.0060214
p_int:  0.999899141
p_ni:  0.000004526
p_wrong:  0.000096334
Score:  0.998
Data Source:  BioPlex,STRINGDB
CHEK1
Tchem
Family:  Kinase
Novelty:  0.00066843
p_int:  0.924718385
p_ni:  0.075281081
p_wrong:  5.33e-7
Score:  0.211
Data Source:  BioPlex,STRINGDB
HSPA5
Tchem
Novelty:  0.00043424
p_int:  0.774931012
p_ni:  0.225068988
Data Source:  BioPlex
UBR3
Tbio
Family:  Enzyme
Novelty:  0.14930754
p_int:  0.76266978
p_ni:  0.23733022
Score:  0.167
Data Source:  BioPlex,STRINGDB
CD74
Tchem
Novelty:  0.00281228
Score:  0.987
Data Source:  STRINGDB
P20039
Tbio
Novelty:  0.00240724
Score:  0.98
Data Source:  STRINGDB
Q9GIY3
Tbio
Novelty:  0.00240724
Score:  0.98
Data Source:  STRINGDB
P01912
Tbio
Novelty:  0.00240724
Score:  0.98
Data Source:  STRINGDB
Q29974
Tbio
Novelty:  0.00240724
Score:  0.98
Data Source:  STRINGDB
Nearest Tclin Targets (2)
Explore Nearest Tclin Targets
1 – 2 of 2
JAK2
Tclin
Family:  Kinase
KEGG Distance:  4
Common Pathways:  7
more:  3 more common pathways
Pathways (120)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Costimulation by the CD28 family
Reactome
Cytokine Signaling in Immune system
Reactome
Downstream TCR signaling
Reactome
Generation of second messenger molecules
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Costimulation by the CD28 family
Cytokine Signaling in Immune system
Downstream TCR signaling
Generation of second messenger molecules
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (163)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
10
10
3
2.1
99.7
6
6
0
2.5
99.2
eosinophil count
4
4
5
98.1
neutrophil count
4
4
4
98.1
8
5
0
1.5
98
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2.1
99.7
0
2.5
99.2
eosinophil count
5
98.1
neutrophil count
4
98.1
0
1.5
98
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
major histocompatibility complex, class II, DR beta 5
462592
Species
Name
OMA
EggNOG
Inparanoid
Chimp
major histocompatibility complex, class II, DR beta 5
Publication Statistics
PubMed Score 460.03
PubMed score by year
PubTator Score 45.38
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title