Tbio SLC4A8 Electroneutral sodium bicarbonate exchanger 1

Protein Summary

Description

Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity. The protein encoded by this gene is a membrane protein that functions to transport sodium and bicarbonate ions across the cell membrane. The encoded protein is important for pH regulation in neurons. The activity of this protein can be inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Uniprot Accession IDs

• Q2Y0W8
• A0MMZ1
• B4DHY0
• E7EML0
• F5GZ31
• F5H7F5
• O94843
• O95233
• Q004B4
• Q8N3U2
• Q8TC60
• Q9UKX8

Gene Name

• SLC4A8

Ensembl ID

• ENST00000358657
• ENSP00000351483
• ENSG00000050438
• ENST00000453097
• ENSP00000405812
• ENST00000514353
• ENSP00000442561
• ENST00000535225
• ENSP00000441520

Symbol

• KIAA0739
• NBC
• NBC3
• NDCBE1
• NBC3
• NDCBE

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.98
molecular function	0.81
histone modification site profile	0.76
protein domain	0.73
disease perturbation	0.68

Protein Classes

PANTHER Classes

Protein / ... / Cation Transporter / Electroneutral Sodium Bicarbonate Exchanger 1

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc4 Family Of Bicarbonate Transporters / Sodium-dependent Hco3- Transporters / Electroneutral Sodium Bicarbonate Exchanger 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.36   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 154   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.36   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0