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Tbio
SLC4A8
Electroneutral sodium bicarbonate exchanger 1

Protein Summary
Description
Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity. The protein encoded by this gene is a membrane protein that functions to transport sodium and bicarbonate ions across the cell membrane. The encoded protein is important for pH regulation in neurons. The activity of this protein can be inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358657
  • ENSP00000351483
  • ENSG00000050438
  • ENST00000453097
  • ENSP00000405812
  • ENST00000514353
  • ENSP00000442561
  • ENST00000535225
  • ENSP00000441520

Symbol
  • KIAA0739
  • NBC
  • NBC3
  • NDCBE1
  • NBC3
  • NDCBE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.98
molecular function
0.81
histone modification site profile
0.76
protein domain
0.73
disease perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.07   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 154   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.07   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (89)
ADCK2
Tbio
Family:  Kinase
Novelty:  0.13237052
p_int:  0.999568372
p_ni:  0.000431626
p_wrong:  2e-9
Score:  0.203
Data Source:  BioPlex,STRINGDB
ADCY3
Tbio
Family:  Enzyme
Novelty:  0.00260265
p_int:  0.998990486
p_ni:  0.001009512
p_wrong:  2e-9
Score:  0.159
Data Source:  BioPlex,STRINGDB
ATP2A3
Tchem
Family:  Transporter
Novelty:  0.0090982
p_int:  0.998053243
p_ni:  0.001946757
Score:  0.233
Data Source:  BioPlex,STRINGDB
SNX14
Tbio
Novelty:  0.10690692
p_int:  0.992428443
p_ni:  0.007571548
p_wrong:  9e-9
Data Source:  BioPlex
TMEM63B
Tdark
Family:  IC
Novelty:  0.25017412
p_int:  0.983183334
p_ni:  0.016816638
p_wrong:  2.7e-8
Data Source:  BioPlex
ABCC4
Tchem
Family:  Transporter
Novelty:  0.00208051
p_int:  0.983021239
p_ni:  0.016978741
p_wrong:  2e-8
Score:  0.234
Data Source:  BioPlex,STRINGDB
C1orf43
Tbio
Novelty:  0.13587458
p_int:  0.98243197
p_ni:  0.017567834
p_wrong:  1.96e-7
Data Source:  BioPlex
PCNX3
Tdark
Novelty:  0.76597717
p_int:  0.982407313
p_ni:  0.017592681
p_wrong:  6e-9
Data Source:  BioPlex
SLC12A6
Tbio
Family:  Transporter
Novelty:  0.0132619
p_int:  0.979300881
p_ni:  0.019229213
p_wrong:  0.001469907
Score:  0.403
Data Source:  BioPlex,STRINGDB
ULBP2
Tbio
Novelty:  0.01604318
p_int:  0.978578349
p_ni:  0.02142164
p_wrong:  1.1e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Bicarbonate transporters (R-HSA-425381)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Bicarbonate transporters
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of inorganic cations/anions and amino acids/oligopeptides
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Bicarbonate transporters
SLC-mediated transmembrane transport
Transport of inorganic cations/anions and amino acids/oligopeptides
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
2
2
2
83.5
alcohol consumption measurement
5
5
5
71.5
alcohol use disorder measurement
2
2
1
5.5
64.2
total cholesterol measurement
1
1
1
44.2
smoking status measurement
1
1
1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
2
83.5
alcohol consumption measurement
5
71.5
alcohol use disorder measurement
1
5.5
64.2
total cholesterol measurement
1
44.2
smoking status measurement
1
40.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 4 member 8
VGNC:8545
451905
Macaque
solute carrier family 4 member 8
695616
Mouse
MGI:1928745
59033
Rat
RGD:735164
315311
Dog
solute carrier family 4 member 8
VGNC:46437
403697
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 4 member 8
Macaque
solute carrier family 4 member 8
Mouse
Rat
Dog
solute carrier family 4 member 8
Publication Statistics
PubMed Score 64.07
PubMed score by year
PubTator Score 12.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title