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Tdark
TMEM249
Transmembrane protein 249

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000565365
  • ENSP00000454468
  • ENSG00000261587
  • ENST00000645530
  • ENSP00000494307
  • ENSG00000285272

Symbol
  • C8orfK29
  • C8ORFK29
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.77
tissue
0.5
cellular component
0.46
gene perturbation
0.4
cell line
0.39


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.04   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 7   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.04   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 7   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
2
2
1
8
94.2
3
3
2
1.1
88.1
sex hormone-binding globulin measurement
4
1
4
80.8
vital capacity
1
1
1
73.3
forced expiratory volume
1
1
1
70.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
8
94.2
2
1.1
88.1
sex hormone-binding globulin measurement
4
80.8
vital capacity
1
73.3
forced expiratory volume
1
70.2
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Dog
transmembrane protein 249
VGNC:47554
100685927
Species
Name
OMA
EggNOG
Inparanoid
Dog
transmembrane protein 249
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q2WGJ8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (1)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (17)
1 – 10 of 17
FBXL6
Tdark
Novelty:  0.33416595
Score:  0.733
Data Source:  STRINGDB
ADCK5
Tdark
Family:  Kinase
Novelty:  1.05895812
Score:  0.731
Data Source:  STRINGDB
WDR97
Tdark
Novelty:  11.62556618
Score:  0.715
Data Source:  STRINGDB
MROH1
Tdark
Novelty:  1.16904275
Score:  0.701
Data Source:  STRINGDB
SCRT1
Tbio
Family:  TF
Novelty:  0.0324512
Score:  0.692
Data Source:  STRINGDB
GPAA1
Tbio
Novelty:  0.01874575
Score:  0.613
Data Source:  STRINGDB
SLC52A2
Tbio
Family:  Transporter
Novelty:  0.02484047
Score:  0.592
Data Source:  STRINGDB
EBF4
Tbio
Family:  TF
Novelty:  0.13329471
Score:  0.59
Data Source:  STRINGDB
EXOSC4
Tbio
Family:  Enzyme
Novelty:  0.00798796
Score:  0.565
Data Source:  STRINGDB
LRRC6
Tbio
Novelty:  0.10994386
Score:  0.55
Data Source:  STRINGDB
Publication Statistics
PubMed Score  0.04

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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