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Tbio
SKOR2
SKI family transcriptional corepressor 2

Protein Summary
Description
Exhibits transcriptional repressor activity (By similarity). Acts as a TGF-beta antagonist in the nervous system.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000400404
  • ENSP00000383255
  • ENSG00000215474

Symbol
  • CORL2
  • FUSSEL18
  • CORL2
  • CH18515
  • FUSSEL18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
biological process
0.62
cell type or tissue
0.5
disease
0.48
cell line
0.46


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.83   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 66   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.83   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
3
2
3
96.8
age at menarche
2
2
1
2.7
86.9
chronotype measurement
1
1
1
69.5
self reported educational attainment
1
1
1
67.2
body mass index
1
1
1
11.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
3
96.8
age at menarche
1
2.7
86.9
chronotype measurement
1
69.5
self reported educational attainment
1
67.2
body mass index
1
11.2
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SKI family transcriptional corepressor 2
VGNC:13285
455405
Mouse
MGI:3645984
664805
Rat
RGD:1598071
681200
Anole lizard
SKI family transcriptional corepressor 2
100566656
Xenopus
SKI family transcriptional corepressor 2 [Source:HGNC Symbol;Acc:HGNC:32695]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SKI family transcriptional corepressor 2
Mouse
Rat
Anole lizard
SKI family transcriptional corepressor 2
Xenopus
SKI family transcriptional corepressor 2 [Source:HGNC Symbol;Acc:HGNC:32695]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q2VWA4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (31)
1 – 10 of 31
HDHD2
Tdark
Family: Enzyme
Novelty: 0.2896237
Score: 0.703
Data Source: STRINGDB
SMAD2
Tbio
Family: TF
Novelty: 0.00040166
Score: 0.668
Data Source: STRINGDB
EVX2
Tbio
Family: TF
Novelty: 0.0506669
Score: 0.606
Data Source: STRINGDB
SMAD3
Tbio
Family: TF
Novelty: 0.00048058
Score: 0.59
Data Source: STRINGDB
KIRREL2
Tbio
Novelty: 0.0349023
Score: 0.589
Data Source: STRINGDB
SLC5A8
Tchem
Family: Transporter
Novelty: 0.00892277
Score: 0.582
Data Source: STRINGDB
TBC1D12
Tdark
Novelty: 0.58439917
Score: 0.557
Data Source: STRINGDB
SEPT9
Tbio
Novelty: 0.00407266
Score: 0.556
Data Source: STRINGDB
IRX1
Tbio
Family: TF
Novelty: 0.01754936
Score: 0.543
Data Source: STRINGDB
NOC3L
Tbio
Novelty: 0.05635731
Score: 0.539
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.83

PubMed score by year
PubTator Score  3.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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