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Tdark
EIF2S3B
Eukaryotic translation initiation factor 2 subunit 3B

Protein Summary
Description
As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (By similarity). Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322446
  • ENSP00000323063
  • ENSG00000180574
  • ENST00000538173
  • ENSP00000445077

Symbol
  • eIF2gA
  • EIF2S3L
  • eIF-2gA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.36   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 14   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.36   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 14   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (178)
1 – 10 of 178
RPS3
Tbio
Novelty:  0.003106
Score:  0.955
Data Source:  STRINGDB
EIF2S1
Tbio
Novelty:  0.00076124
Score:  0.953
Data Source:  STRINGDB
EIF3G
Tbio
Novelty:  0.04737601
Score:  0.927
Data Source:  STRINGDB
EPRS
Tchem
Family:  Enzyme
Novelty:  0.00084896
Score:  0.923
Data Source:  STRINGDB
EIF2S2
Tbio
Novelty:  0.0146918
Score:  0.913
Data Source:  STRINGDB
RPS6
Tbio
Novelty:  0.00122241
Score:  0.905
Data Source:  STRINGDB
EIF3B
Tbio
Novelty:  0.00889042
Score:  0.903
Data Source:  STRINGDB
EIF3E
Tbio
Novelty:  0.02154456
Score:  0.899
Data Source:  STRINGDB
RPSA
Tbio
Novelty:  0.00250446
Score:  0.897
Data Source:  STRINGDB
EIF3A
Tbio
Novelty:  0.00434615
Score:  0.891
Data Source:  STRINGDB
Gene Ontology Terms (7)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
2
2
92.1
monocyte count
2
2
2
87.2
serum alanine aminotransferase measurement
2
2
1
7
83.6
neutrophil percentage of leukocytes
2
2
2
83.6
mean corpuscular volume
1
1
1
79.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
92.1
monocyte count
2
87.2
serum alanine aminotransferase measurement
1
7
83.6
neutrophil percentage of leukocytes
2
83.6
mean corpuscular volume
1
79.3
Find similar targets by:
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
putative eukaryotic translation initiation factor 2 subunit 3-like protein
738402
Opossum
eukaryotic translation initiation factor 2 subunit gamma
100010358
Platypus
eukaryotic translation initiation factor 2 subunit gamma
100082513
Chicken
eukaryotic translation initiation factor 2 subunit gamma
CGNC:50802
418597
Xenopus
eukaryotic translation initiation factor 2 subunit gamma
XB-GENE-986363
496946
Species
Name
OMA
EggNOG
Inparanoid
Chimp
putative eukaryotic translation initiation factor 2 subunit 3-like protein
Opossum
eukaryotic translation initiation factor 2 subunit gamma
Platypus
eukaryotic translation initiation factor 2 subunit gamma
Chicken
eukaryotic translation initiation factor 2 subunit gamma
Xenopus
eukaryotic translation initiation factor 2 subunit gamma
Publication Statistics
PubMed Score 0.36
PubMed score by year