Tdark COL28A1 Collagen alpha-1(XXVIII) chain

Protein Classes

PANTHER Classes

Protein / Extracellular Matrix Protein / Extracellular Matrix Structural Protein / Collagen Alpha-1(xxviii) Chain

DTO Classes

Protein / Extracellular Structure / Extracellular Matrix Structural Protein / Collagen Alpha-1(xxviii) Chain

Protein Summary

Description

May act as a cell-binding protein. COL28A1 belongs to a class of collagens containing von Willebrand factor (VWF; MIM 613160) type A (VWFA) domains (Veit et al., 2006 [PubMed 16330543]).[supplied by OMIM, Nov 2010]

Uniprot Accession IDs

• Q2UY09
• A4D101
• A4D106
• A4D107
• A8MVR2
• B9EGX9
• Q2UY07
• Q2UY08

Gene Name

• COL28A1

Ensembl ID

• ENST00000399429
• ENSP00000382356
• ENSG00000215018

Symbol

• COL28
• COL28

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.7
tissue	0.62
protein domain	0.58
phenotype	0.57
cell line	0.56

Related Tools

GENEVA

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.66   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 18   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.66   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 18   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (5)

1 – 5 of 5

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	collagen, type XXVIII, alpha 1	MGI:2685312	213945
Dog	collagen type XXVIII alpha 1 chain	VGNC:39470	482315
Horse	collagen type XXVIII alpha 1 chain	VGNC:16736	100063901
Anole lizard	collagen type XXVIII alpha 1 chain		100562364
Xenopus	collagen type XXVIII alpha 1 chain [Source:HGNC Symbol;Acc:HGNC:22442]

Species	Name	OMA	EggNOG	Inparanoid
Mouse	collagen, type XXVIII, alpha 1
Dog	collagen type XXVIII alpha 1 chain
Horse	collagen type XXVIII alpha 1 chain
Anole lizard	collagen type XXVIII alpha 1 chain
Xenopus	collagen type XXVIII alpha 1 chain [Source:HGNC Symbol;Acc:HGNC:22442]

Protein Structure (0 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q2UY09-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)

Reactome (4)

KEGG (1)

Collagen biosynthesis and modifying enzymes (R-HSA-1650814)

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Find Similar Targets

Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Collagen biosynthesis and modifying enzymes	67 targets	R-HSA-1650814
Reactome	Collagen chain trimerization	44 targets	R-HSA-8948216
Reactome	Collagen formation	90 targets	R-HSA-1474290
Reactome	Extracellular matrix organization	297 targets	R-HSA-1474244

Name	Explore in Pharos	Explore in Source
Collagen biosynthesis and modifying enzymes	67 targets	R-HSA-1650814
Collagen chain trimerization	44 targets	R-HSA-8948216
Collagen formation	90 targets	R-HSA-1474290
Extracellular matrix organization	297 targets	R-HSA-1474244

Gene Ontology Terms (12)

Functions (3)

Components (7)

Processes (2)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
extracellular matrix structural constituent conferring tensile strength	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL
extracellular matrix structural constituent	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
serine-type endopeptidase inhibitor activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (79)

Explore Interacting Targets

1 – 10 of 79

• See Interactions on String-DB

COL4A6

Tbio

Novelty: 0.02524039

Score: 0.927

Data Source: STRINGDB

COL1A1

Tbio

Novelty: 0.00063584

Score: 0.927

Data Source: STRINGDB

COL27A1

Tbio

Novelty: 0.03450245

Score: 0.924

Data Source: STRINGDB

COL22A1

Tbio

Novelty: 0.12180316

Score: 0.923

Data Source: STRINGDB

COL5A3

Tbio

Novelty: 0.06365591

Score: 0.922

Data Source: STRINGDB

COL4A2

Tbio

Novelty: 0.00782053

Score: 0.921

Data Source: STRINGDB

COL1A2

Tbio

Novelty: 0.00048334

Score: 0.921

Data Source: STRINGDB

COL4A4

Tbio

Novelty: 0.00833684

Score: 0.92

Data Source: STRINGDB

COL14A1

Tbio

Novelty: 0.01760399

Score: 0.918

Data Source: STRINGDB

P3H2

Tbio

Family: Enzyme

Novelty: 0.04237396

Score: 0.918

Data Source: STRINGDB

Publication Statistics

PubMed Score  0.66

PubMed score by year

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PubTator Score  1.2

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

Alternative splicing
Basement membrane
Cell adhesion
Collagen
Complete proteome
Disulfide bond
Extracellular matrix
Polymorphism
Protease inhibitor
Reference proteome