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Tdark
COL28A1
Collagen alpha-1(XXVIII) chain

Protein Summary
Description
May act as a cell-binding protein. COL28A1 belongs to a class of collagens containing von Willebrand factor (VWF; MIM 613160) type A (VWFA) domains (Veit et al., 2006 [PubMed 16330543]).[supplied by OMIM, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000399429
  • ENSP00000382356
  • ENSG00000215018

Symbol
  • COL28
  • COL28
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.7
tissue
0.62
protein domain
0.58
phenotype
0.57
cell line
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.66   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 18   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.66   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 18   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (79)
COL4A6
Tbio
Novelty:  0.02524039
Score:  0.927
Data Source:  STRINGDB
COL1A1
Tbio
Novelty:  0.00063584
Score:  0.927
Data Source:  STRINGDB
COL27A1
Tbio
Novelty:  0.03450245
Score:  0.924
Data Source:  STRINGDB
COL22A1
Tbio
Novelty:  0.12180316
Score:  0.923
Data Source:  STRINGDB
COL5A3
Tbio
Novelty:  0.06365591
Score:  0.922
Data Source:  STRINGDB
COL4A2
Tbio
Novelty:  0.00782053
Score:  0.921
Data Source:  STRINGDB
COL1A2
Tbio
Novelty:  0.00048334
Score:  0.921
Data Source:  STRINGDB
COL4A4
Tbio
Novelty:  0.00833684
Score:  0.92
Data Source:  STRINGDB
COL14A1
Tbio
Novelty:  0.01760399
Score:  0.918
Data Source:  STRINGDB
P3H2
Tbio
Family:  Enzyme
Novelty:  0.04237396
Score:  0.918
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Collagen biosynthesis and modifying enzymes (R-HSA-1650814)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen chain trimerization
Reactome
Collagen formation
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Collagen biosynthesis and modifying enzymes
Collagen chain trimerization
Collagen formation
Extracellular matrix organization
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
1
1
12.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
12.9
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2685312
213945
Dog
collagen type XXVIII alpha 1 chain
VGNC:39470
482315
Horse
collagen type XXVIII alpha 1 chain
VGNC:16736
100063901
Anole lizard
collagen type XXVIII alpha 1 chain
100562364
Xenopus
collagen type XXVIII alpha 1 chain [Source:HGNC Symbol;Acc:HGNC:22442]
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
collagen type XXVIII alpha 1 chain
Horse
collagen type XXVIII alpha 1 chain
Anole lizard
collagen type XXVIII alpha 1 chain
Xenopus
collagen type XXVIII alpha 1 chain [Source:HGNC Symbol;Acc:HGNC:22442]
Publication Statistics
PubMed Score 0.66
PubMed score by year
PubTator Score 1.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title