Tdark CWF19L2 CWF19-like protein 2

Protein Summary

Uniprot Accession IDs

• Q2TBE0
• A4FU66
• A4FU67
• A4FU68
• A8KAD6
• Q6PHW1
• Q96MI1

Gene Name

• CWF19L2

Ensembl ID

• ENST00000282251
• ENSP00000282251
• ENSG00000152404

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.88
ligand (protein) perturbation	0.83
cell type or tissue	0.71
transcription factor binding site profile	0.69
transcription factor perturbation	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.03   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 34   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.03   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 34   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (69)

Explore Interacting Targets

1 – 10 of 69

• See Interactions on String-DB

BCAS2

Tbio

Novelty:  0.05425016

p_int:  0.999998032

p_ni:  0.000001968

Score:  0.67

Data Source:  BioPlex,STRINGDB

SNRPE

Tbio

Novelty:  0.02033423

p_int:  0.999989654

p_ni:  0.000010346

Score:  0.816

Data Source:  BioPlex,STRINGDB

PRPF19

Tbio

Novelty:  0.01616737

p_int:  0.9999877

p_ni:  0.00001226

p_wrong:  4e-8

Score:  0.925

Data Source:  BioPlex,STRINGDB

SNW1

Tbio

Novelty:  0.01423797

p_int:  0.999985144

p_ni:  0.000014856

Score:  0.747

Data Source:  BioPlex,STRINGDB

NEU2

Tbio

Family:  Enzyme

Novelty:  0.00460828

p_int:  0.999969316

p_ni:  0.000030684

Data Source:  BioPlex

ELAVL2

Tbio

Novelty:  0.00370708

p_int:  0.999967625

p_ni:  0.000032374

Data Source:  BioPlex

TSSC4

Tdark

Novelty:  0.17064786

p_int:  0.999965477

p_ni:  0.000034523

Score:  0.571

Data Source:  BioPlex,STRINGDB

SYF2

Tbio

Novelty:  0.06114903

p_int:  0.999951036

p_ni:  0.000048964

Score:  0.833

Data Source:  BioPlex,STRINGDB

USB1

Tbio

Family:  Enzyme

Novelty:  0.01677996

p_int:  0.99993942

p_ni:  0.000060579

p_wrong:  2e-9

Score:  0.725

Data Source:  BioPlex,STRINGDB

SNRPB2

Tbio

Novelty:  0.17219587

p_int:  0.999892852

p_ni:  0.000107148

Score:  0.394

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (0)

No GO Terms found

Disease Associations ()

No disease associations found

GWAS Traits (5)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
intraocular pressure measurement	EFO_0004695	1	1	1		76.8
Agents acting on the renin-angiotensin system use measurement	EFO_0009931	1	1	1		6.6
self reported educational attainment	EFO_0004784	1	1	1		6
Beta blocking agent use measurement	EFO_0009929	1	1	1		3.1
Diuretic use measurement	EFO_0009928	1	1	1		1.8

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
intraocular pressure measurement	EFO_0004695	1		76.8
Agents acting on the renin-angiotensin system use measurement	EFO_0009931	1		6.6
self reported educational attainment	EFO_0004784	1		6
Beta blocking agent use measurement	EFO_0009929	1		3.1
Diuretic use measurement	EFO_0009928	1		1.8

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Coiled coil
Complete proteome
Isopeptide bond
Phosphoprotein
Polymorphism
Reference proteome
Ubl conjugation

GWAS Trait Find Similar Targets

No Header	No Header
Agents acting on the renin-angiotensin system use measurement
Beta blocking agent use measurement
Diuretic use measurement
intraocular pressure measurement
self reported educational attainment

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	CWF19 like 2, cell cycle control (S. pombe)		466771
Macaque	CWF19 like 2, cell cycle control (S. pombe)		706825
Mouse	CWF19-like 2, cell cycle control (S. pombe)	MGI:1918023	244672
Rat	CWF19-like 2, cell cycle control (S. pombe)	RGD:1310083	362804
Dog	CWF19 like 2, cell cycle control (S. pombe)		479454

Species	Name	OMA	EggNOG	Inparanoid
Chimp	CWF19 like 2, cell cycle control (S. pombe)
Macaque	CWF19 like 2, cell cycle control (S. pombe)
Mouse	CWF19-like 2, cell cycle control (S. pombe)
Rat	CWF19-like 2, cell cycle control (S. pombe)
Dog	CWF19 like 2, cell cycle control (S. pombe)

Publication Statistics

PubMed Score 1.03

PubMed score by year

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PubTator Score 0.14

PubTator score by year

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Related Publications

Text Mined References (7)

GeneRif Annotations (2)

Items per page:

10

0 of 0

PMID	Year	Title