You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
KLHL40
Kelch-like protein 40

Protein Summary
Description
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development (PubMed:23746549). The BCR(KLHL40) complex acts by mediating ubiquitination and degradation of TFDP1, thereby regulating the activity of the E2F:DP transcription factor complex (By similarity). Promotes stabilization of LMOD3 by acting as a negative regulator of LMOD3 ubiquitination; the molecular process by which it negatively regulates ubiquitination of LMOD3 is however unclear (By similarity). This gene encodes a protein containing a BACK domain, a BTB/POZ domain, and 5 Kelch repeats, however, its exact function is not known. The gene and the multi-domain protein structure are conserved across different taxa, including primates, rodents, chicken and zebrafish. [provided by RefSeq, Dec 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287777
  • ENSP00000287777
  • ENSG00000157119

Symbol
  • KBTBD5
  • SRYP
  • NEM8
  • SRYP
  • SYRP
  • KBTBD5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
gene perturbation
0.76
cell line
0.61
PubMedID
0.51
transcription factor
0.44


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.35   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 104   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.35   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (83)
CEP85L
Tbio
Novelty:  0.23631446
p_int:  0.999999965
p_ni:  6e-9
p_wrong:  2.9e-8
Score:  0.189
Data Source:  BioPlex,STRINGDB
ZNF106
Tbio
Novelty:  0.17021565
p_int:  0.999998874
p_ni:  0.000001126
Score:  0.155
Data Source:  BioPlex,STRINGDB
ZNF746
Tbio
Family:  TF
Novelty:  0.10426864
p_int:  0.999998736
p_ni:  0.000001264
Score:  0.196
Data Source:  BioPlex,STRINGDB
DUSP11
Tbio
Family:  Enzyme
Novelty:  0.01548269
p_int:  0.999997182
p_ni:  0.000002818
Score:  0.159
Data Source:  BioPlex,STRINGDB
ZNF81
Tbio
Family:  TF
Novelty:  0.19441315
p_int:  0.999994573
p_wrong:  0.000005426
Score:  0.356
Data Source:  BioPlex,STRINGDB
KLHL41
Tbio
Novelty:  0.03973182
p_int:  0.999989594
p_ni:  4.4e-8
p_wrong:  0.000010362
Score:  0.431
Data Source:  BioPlex,STRINGDB
SLAIN1
Tdark
Novelty:  0.20438696
p_int:  0.999963844
p_ni:  0.000035641
p_wrong:  5.15e-7
Score:  0.163
Data Source:  BioPlex,STRINGDB
MCM10
Tbio
Novelty:  0.0136058
p_int:  0.999918908
p_ni:  0.000081092
p_wrong:  1e-9
Score:  0.305
Data Source:  BioPlex,STRINGDB
ZBTB5
Tbio
Novelty:  0.50774653
p_int:  0.999788979
p_ni:  0.000210907
p_wrong:  1.14e-7
Score:  0.196
Data Source:  BioPlex,STRINGDB
TBC1D2B
Tdark
Novelty:  0.52348266
p_int:  0.999719977
p_ni:  0.000280023
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eotaxin measurement
1
1
1
76.6
monocyte chemotactic protein 1 measurement
1
1
1
48.5
body fat distribution
1
1
1
17.8
CCL2 measurement
1
1
1
5.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eotaxin measurement
1
76.6
monocyte chemotactic protein 1 measurement
1
48.5
body fat distribution
1
17.8
CCL2 measurement
1
5.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 40
VGNC:6353
470802
Mouse
MGI:1919580
72330
Rat
RGD:1305368
316088
Cow
kelch like family member 40
VGNC:30665
514526
Pig
kelch like family member 40
100523695
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 40
Mouse
Rat
Cow
kelch like family member 40
Pig
kelch like family member 40
Publication Statistics
PubMed Score 22.35
PubMed score by year
PubTator Score 6.55
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title