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Tbio
HKDC1
Putative hexokinase HKDC1

Protein Summary
Description
This gene encodes a member of the hexokinase protein family. The encoded protein is involved in glucose metabolism, and reduced expression may be associated with gestational diabetes mellitus. High expression of this gene may also be associated with poor prognosis in hepatocarcinoma. [provided by RefSeq, Sep 2016]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
gene perturbation
0.78
interacting protein
0.7
transcription factor perturbation
0.68
tissue sample
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.5   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.5   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
3
2
3
95.1
sex hormone-binding globulin measurement
2
1
2
91
glucose tolerance test
1
1
1
83.9
C-peptide measurement
1
1
1
83.9
fasting blood glucose measurement
1
1
1
83.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
3
95.1
sex hormone-binding globulin measurement
2
91
glucose tolerance test
1
83.9
C-peptide measurement
1
83.9
fasting blood glucose measurement
1
83.9
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hexokinase domain containing 1
VGNC:4711
450504
Macaque
hexokinase domain containing 1
711995
Mouse
MGI:2384910
216019
Dog
hexokinase domain containing 1
VGNC:41701
489019
Horse
hexokinase domain containing 1
VGNC:18798
100072686
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hexokinase domain containing 1
Macaque
hexokinase domain containing 1
Mouse
Dog
hexokinase domain containing 1
Horse
hexokinase domain containing 1
Pathways (25)
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Central carbon metabolism in cancer
KEGG
Glycolysis / Gluconeogenesis
KEGG
Fructose and mannose metabolism
KEGG
Type II diabetes mellitus
KEGG
HIF-1 signaling pathway
Name
Explore in Pharos
Explore in Source
Central carbon metabolism in cancer
Glycolysis / Gluconeogenesis
Fructose and mannose metabolism
Type II diabetes mellitus
HIF-1 signaling pathway
Gene Ontology Terms (10)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (89)
1 – 10 of 89
HK1
Tchem
Family: Kinase
Novelty: 0.00195554
p_int: 1
Score: 0.986
Data Source: BioPlex,STRINGDB
HK3
Tbio
Family: Kinase
Novelty: 0.0151241
p_int: 0.999999936
p_ni: 2.6e-8
p_wrong: 3.8e-8
Score: 0.967
Data Source: BioPlex,STRINGDB
GPI
Tbio
Family: Enzyme
Novelty: 0.00095404
Score: 0.949
Data Source: STRINGDB
MPI
Tchem
Family: Enzyme
Novelty: 0.0091718
Score: 0.947
Data Source: STRINGDB
GNPNAT1
Tbio
Family: Enzyme
Novelty: 0.01739665
Score: 0.942
Data Source: STRINGDB
FBP2
Tbio
Family: Enzyme
Novelty: 0.00854851
Score: 0.941
Data Source: STRINGDB
PGM1
Tbio
Family: Enzyme
Novelty: 0.00163947
Score: 0.94
Data Source: STRINGDB
FBP1
Tchem
Family: Enzyme
Novelty: 0.0029987
Score: 0.935
Data Source: STRINGDB
GFPT1
Tchem
Family: Enzyme
Novelty: 0.00358283
Score: 0.929
Data Source: STRINGDB
GNPDA2
Tbio
Family: Enzyme
Novelty: 0.02712908
Score: 0.925
Data Source: STRINGDB
Publication Statistics
PubMed Score  58.50

PubMed score by year
PubTator Score  7.27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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