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Tbio
ATG2A
Autophagy-related protein 2 homolog A

Protein Summary
Description
Involved in autophagosome assembly, regulating the size of nascent autophagosomes (PubMed:28561066). Also regulates lipid droplets morphology and distribution within the cell (PubMed:22219374, PubMed:28561066).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377264
  • ENSP00000366475
  • ENSG00000110046
  • ENST00000421419
  • ENSP00000410522

Symbol
  • KIAA0404
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.89
transcription factor
0.79
histone modification site profile
0.75
kinase perturbation
0.71
tissue sample
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.05   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 144   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.05   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 144   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (9)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (64)
1 – 10 of 64
UBTD1
Tdark
Novelty: 0.50393104
p_int: 0.999666857
p_ni: 0.000012825
p_wrong: 0.000320318
Data Source: BioPlex
RFTN1
Tbio
Novelty: 0.08295743
p_int: 0.997685999
p_ni: 0.000010135
p_wrong: 0.002303865
Score: 0.723
Data Source: BioPlex,STRINGDB
WIPI1
Tbio
Novelty: 0.01070744
Score: 0.975
Data Source: STRINGDB
WIPI2
Tbio
Novelty: 0.02685992
Score: 0.969
Data Source: STRINGDB
ULK1
Tchem
Family: Kinase
Novelty: 0.00240301
Score: 0.938
Data Source: STRINGDB
ULK2
Tchem
Family: Kinase
Novelty: 0.02285321
Score: 0.926
Data Source: STRINGDB
WDR45
Tbio
Novelty: 0.0148072
Score: 0.867
Data Source: STRINGDB
ATG9A
Tbio
Novelty: 0.01995033
Score: 0.858
Data Source: STRINGDB
ATG2B
Tbio
Novelty: 0.04963717
Score: 0.854
Data Source: STRINGDB
ATG4A
Tbio
Family: Enzyme
Novelty: 0.04073485
Score: 0.787
Data Source: STRINGDB
Publication Statistics
PubMed Score  17.05

PubMed score by year
PubTator Score  5.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer