Tbio ATG2A Autophagy-related protein 2 homolog A

Protein Summary

Description

Involved in autophagosome assembly, regulating the size of nascent autophagosomes (PubMed:28561066). Also regulates lipid droplets morphology and distribution within the cell (PubMed:22219374, PubMed:28561066).

Uniprot Accession IDs

• Q2TAZ0
• O43154
• Q14DM2
• Q6ZTV2
• Q7Z6K8
• Q8IVY5
• Q8TAI8
• Q96HH7

Gene Name

• ATG2A

Ensembl ID

• ENST00000377264
• ENSP00000366475
• ENSG00000110046
• ENST00000421419
• ENSP00000410522

Symbol

• KIAA0404

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.89
transcription factor	0.79
histone modification site profile	0.75
kinase perturbation	0.71
tissue sample	0.69

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.77   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 144   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.77   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 144   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0