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Tbio
SMU1
WD40 repeat-containing protein SMU1

Protein Summary
Description
Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:28781166). Regulates alternative splicing of the HSPG2 pre-mRNA (By similarity). Required for normal accumulation of IK (PubMed:24945353). Required for normal mitotic spindle assembly and normal progress through mitosis (By similarity). (Microbial infection) Required, together with IK, for normal splicing of influenza A virus NS1 pre-mRNA, which is required for the production of the exportin NS2 and for the production of influenza A virus particles. Not required for the production of VSV virus particles.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397149
  • ENSP00000380336
  • ENSG00000122692

Symbol
  • BWD
  • SMU-1
  • fSAP57
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
protein domain
0.92
interacting protein
0.85
virus perturbation
0.83
disease perturbation
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.24   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.24   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
79.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
79.4
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SMU1, DNA replication regulator and spliceosomal factor
VGNC:10451
465038
Macaque
SMU1, DNA replication regulator and spliceosomal factor
703656
Mouse
MGI:1915546
74255
Rat
RGD:620694
117541
Dog
SMU1, DNA replication regulator and spliceosomal factor
VGNC:46578
474740
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SMU1, DNA replication regulator and spliceosomal factor
Macaque
SMU1, DNA replication regulator and spliceosomal factor
Mouse
Rat
Dog
SMU1, DNA replication regulator and spliceosomal factor
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q2TAY7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (7)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (158)
1 – 10 of 158
IK
Tbio
Novelty: 0.01510642
p_int: 0.999999996
p_ni: 4e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
PRPF8
Tbio
Novelty: 0.01717158
Score: 0.998
Data Source: STRINGDB
SF3B1
Tbio
Novelty: 0.0128965
Score: 0.997
Data Source: STRINGDB
SF3B3
Tchem
Novelty: 0.02866311
Score: 0.997
Data Source: STRINGDB
PRPF31
Tbio
Novelty: 0.0105753
Score: 0.997
Data Source: STRINGDB
SNRPA1
Tbio
Novelty: 0.01232044
Score: 0.996
Data Source: STRINGDB
SF3B5
Tdark
Novelty: 0.26636354
Score: 0.996
Data Source: STRINGDB
SNU13
Tbio
Novelty: 0.01613497
Score: 0.996
Data Source: STRINGDB
SNRPB
Tbio
Novelty: 0.01503535
Score: 0.996
Data Source: STRINGDB
PRPF3
Tbio
Novelty: 0.01600014
Score: 0.996
Data Source: STRINGDB
Publication Statistics
PubMed Score  46.24

PubMed score by year
PubTator Score  23.86

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer